Synthesis of radioactive gold nanoparticle in surfactant medium

Mandal, Subinay

doi:10.1007/s10967-013-2602-z

Cited by 20 publications

(4 citation statements)

References 21 publications

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“…The unique property of gold nanoparticles is that they accumulate inside the target cancer cells and could be display optical scattering. Several methodologies have been adapted to synthesize gold nanoparticles, which include chemical, electrochemical, thermal, and sono-chemical methods (Yu, Chang et al 1997, Mandal 2014). Among them, the chemical methods are easiest, provide better yield, and also the particles formed are relatively more uniform and stable in aqueous systems.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Metallic Nanocarriers for Therapeutic Peptides: Emerging Solutions Addressing the Delivery Challenges in Brain Ailments

Rathnam,

Deepak,

Sahoo

et al. 2024

The Journal of Pharmacology and Experimental Therapeutics

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Peptides and proteins have recently emerged as efficient therapeutic alternatives to conventional therapies. Although their advent a few decades back, extensive exploration of various ailments or disorders began recently. The drawbacks of current chemotherapies and irradiation treatments, such as drug resistance and damage to healthy tissues, have enabled the rise of peptides in the quest for better prospects. The chemical tunability and smaller size make them easy to design selectively for target tissues. Other remarkable properties include antifungal, antiviral, antiinflammatory, protection from hemorrhage stroke, and as therapeutic agents for gastric disorders, Alzheimer's, and Parkinson's diseases. Despite these unmatched properties, their practical applicability is often hindered due to their weak susceptibility to enzymatic digestion, serum degradation, liver metabolism, kidney clearance, and immunogenic reactions. Several methods are adapted to increase the half-life of peptides, such as chemical modifications, fusing with Fc fragment, change in amino acid composition, and carrier-based delivery. Among these, nanocarrier-mediated encapsulation not only increases the half-life of the peptides in vivo but also aids in the targeted delivery. Despite its structural complexity, they also efficiently deliver therapeutic molecules across the blood-brain barrier (BBB). Here, in this review, we tried to emphasize the possible potentiality of metallic nanoparticles to be used as an efficient peptide delivery system against brain tumors and neurodegenerative disorders.

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Section: Gold Nanoparticlesmentioning

confidence: 99%

Metallic Nanocarriers for Therapeutic Peptides: Emerging Solutions Addressing the Delivery Challenges in Brain Ailments

Rathnam,

Deepak,

Sahoo

et al. 2024

The Journal of Pharmacology and Experimental Therapeutics

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“…Gold nanoparticles (AuNPs) have received more attention in electrochemical and biosensor applications because of the most stable metal nanoparticles and easy to synthesize in various sizes; there is a protocol to modify these nanoparticles with additional functionality, and they possess unique properties such as strong adsorption ability, large specific surface area, good biocompatibility, and conductivity [ 25 , 26 , 27 , 28 ]. Various techniques are available for synthesizing AuNPs, including chemical, thermal, electrochemical, and sonochemical methods [ 29 ]. The electrochemical method has been verified to be superior to other methods due to its modest equipment, low cost, lower processing temperature, high quality, and ease of controlling the yield [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Defects of Carbon Nanomaterials in the Detection of Ovarian Cancer Cells in Label-Free Electrochemical Immunosensors

Runprapan

Wang

Ramar

et al. 2023

Sensors

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Developing label-free immunosensors to detect ovarian cancer (OC) by cancer antigen (CA125) is essential to improving diagnosis and protecting women from life-threatening diseases. Four types of carbon nanomaterials, such as multi-wall carbon nanotubes (MWCNTs), vapor-grown carbon fiber (VGCFs), graphite KS4, and carbon black super P (SP), have been treated with acids to prepare a carbon nanomaterial/gold (Au) nanocomposite. The AuNPs@carbon nanocomposite was electrochemically deposited on a glassy carbon electrode (GCE) to serve as a substrate to fabricate a label-free immunosensor for the detection of CA125. Among the four AuNPs@carbon composite, the AuNPs@MWCNTs-based sensor exhibited a high sensitivity of 0.001 µg/mL for the biomarker CA125 through the square wave voltammetry (SWV) technique. The high conductivity and surface area of MWCNTs supported the immobilization of AuNPs. Moreover, the carboxylic (COO-) functional groups in MWCNT improved to a higher quantity after the acid treatment, which served as an excellent support for the fabrication of electrochemical biosensors. The present method aims to explore an environmentally friendly synthesis of a layer-by-layer (LBL) assembly of AuNPs@carbon nanomaterials electrochemical immunoassay to CA125 in a clinical diagnosis at a low cost and proved feasible for point-of-care diagnosis.

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“…AuNPs can be synthesized tuning size and shape particles by different strategies; for instance, thermal, electrochemical, chemical methods, and biosynthesis (15)(16)(17)(18)(19)(20)(21). Particularly, chemical methods use a gold salt (Au 3+ ) precursor and different reducing agents, such as sodium borohydride, sugars, polyols, gallic acid (GA), and citric acid (CA).…”

Section: Introductionmentioning

confidence: 99%

Two Methods of AuNPs Synthesis Induce Differential Vascular Effects. The Role of the Endothelial Glycocalyx

et al. 2022

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AuNPs are synthesized through several methods to tune their physicochemical properties. Although AuNPs are considered biocompatible, a change in morphology or properties can modify their biological impact. In this work, AuNPs (~12 to 16 nm) capping with either sodium citrate (CA) or gallic acid (GA) were evaluated in a rat aorta ex vivo model, which endothelial inner layer surface is formed by glycocalyx (hyaluronic acid, HA, as the main component), promoting vascular processes, most of them dependent on nitric oxide (NO) production. Results showed that contractile effects were more evident with AuNPsCA, while dilator effects predominated with AuNPsGA. Furthermore, treatments with AuNPsCA and AuNPsGA in the presence or absence of glycocalyx changed the NO levels, differently. This work contributes to understanding the biological effects of AuNPs with different capping agents, as well as the key role that of HA in the vascular effects induced by AuNPs in potential biomedical applications.

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Synthesis of radioactive gold nanoparticle in surfactant medium

Cited by 20 publications

References 21 publications

Metallic Nanocarriers for Therapeutic Peptides: Emerging Solutions Addressing the Delivery Challenges in Brain Ailments

Metallic Nanocarriers for Therapeutic Peptides: Emerging Solutions Addressing the Delivery Challenges in Brain Ailments

Role of Defects of Carbon Nanomaterials in the Detection of Ovarian Cancer Cells in Label-Free Electrochemical Immunosensors

Two Methods of AuNPs Synthesis Induce Differential Vascular Effects. The Role of the Endothelial Glycocalyx

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