Synthesis of Resins via Multiparallel Suspension Polymerization

Alesso, Sonia; Yu, Zhanru; Pears, D. A.; Worthington, Philip; Luke, Richard; Bradley, Mark

doi:10.1021/cc010045b

Cited by 22 publications

(12 citation statements)

References 5 publications

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“…After the previously reported automated parallel suspension polymerization of styrene, divinylbenzene, and vinylbenzylchloride by Bradley and co-workers, [34] the first example of automated parallel emulsion polymerization has been reported by Schubert, Van Herk and co-workers. [35] Emulsion polymerizations were performed in five parallel reactors utilizing well-defined systems of styrene and vinyl acetate, whereby the vortex speed was identified as an important parameter to obtain suitable emulsions.…”

Section: Free Radical Polymerizationmentioning

confidence: 99%

Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: The Evolution Continues

Meier¹,

Hoogenboom²,

Schubert³

2003

Macromol. Rapid Commun.

120

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Summary: For speeding‐up preparation as well as investigating new polymeric materials, combinatorial techniques, parallel experimentation, and high‐throughput screening methods represent a very promising approach in polymer chemistry: a large variety of parameters can be screened simultaneously resulting in new structure–property relationships. As previously described, polymer chemistry seems to be perfectly suited for combinatorial approaches since it is relatively easy to vary many parameters during the synthesis, processing, blending, or compounding. Moreover, the development and application of high‐throughput screening techniques for polymer properties can accelerate the development of new materials and can result in new structure–property relationships. Therefore, these screening tools, together with parallel preparation techniques, will significantly decrease the time to market of new products. Here we provide an update of our recent overview covering new developments in the field of combinatorial and parallel polymer synthesis and high‐throughput screening.Development of high‐throughput screening techniques for polymer properties.magnified imageDevelopment of high‐throughput screening techniques for polymer properties.

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Section: Free Radical Polymerizationmentioning

confidence: 99%

Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: The Evolution Continues

Meier¹,

Hoogenboom²,

Schubert³

2003

Macromol. Rapid Commun.

120

View full text Add to dashboard Cite

show abstract

“…[45][46][47] This system was used to perform the parallel synthesis of a set of polystyrene resins. Polymerizations with varying ratios of divinylbenzene (DVB), styrene and vinylbenzyl chloride were thermally initiated with 2,2 0 -azoisobutyronitrile (AIBN).…”

Section: Free-radical Polymerizationmentioning

confidence: 99%

Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: Past and Present

Hoogenboom

Meier

Schubert

2003

Macromol. Rapid Commun.

204

160

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Combinatorial techniques, parallel experimentation and high‐throughput methods represent a very promising approach in order to speed up the preparation and investigation of new polymeric materials: a large variety of parameters can be screened simultaneously resulting in new structure/property relationships. The field of polymer research seems to be perfectly suited for parallel and combinatorial methods due to the fact that many parameters can be varied during synthesis, processing, blending as well as compounding. In addition, numerous important parameters have to be investigated, such as molecular weight, polydispersity, viscosity, hardness, stiffness and other application‐specific properties. A number of corresponding high‐throughput techniques have been developed in the last few years and their introduction into the commercial market further boosted the development. These combinatorial approaches can reduce the time‐to‐market for new polymeric materials drastically compared to traditional approaches and allow a much more detailed understanding of polymers from the macroscopic to the nanoscopic scale. Here we provide an overview of the present status of combinatorial and parallel polymer synthesis and high‐throughput screening.magnified image

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“…No more than one semiautomated (manual-filling) example on suspension polymerization has been reported utilizing six large-scale (500-mL) parallel reactors equipped with mechanical stirrers. 27 However, emulsion polymerizations are especially interesting for the ease of product isolation and handling. Stirred tank reactors are used for emulsion polymerizations, particularly for semibatch operations.…”

Section: Emulsion Polymerizationmentioning

confidence: 99%

“…Moreover, both free-and controlled radical polymerizations have been described in the literature. Alesso et al 27 synthesized several polystyrene beads via automated suspension free-radical polymerization of styrene and divinylbenzene, and Voorn et al 28 demonstrated the successful application of automated parallel methods to the emulsion polymerization of styrene and vinyl acetate. Other combinatorial and automated free-radical polymerizations in solution were reported by Gravert et al, 29 Lanza et al, 30,31 Williamson and Long, 32 as well as Symyx.…”

Section: Introductionmentioning

confidence: 99%

The fast and the curious: High‐throughput experimentation in synthetic polymer chemistry

Hoogenboom

Schubert

2003

J. Polym. Sci. A Polym. Chem.

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ABSTRACT:The application of automated synthetic parallel methods in polymer chemistry is described. A brief overview of all different polymerization techniques that have been used is provided. Furthermore, the equipment and methodologies that were used in our approach for automated parallel polymerization reactions are discussed followed by detailed insight into recent developments on automated cationic ring-opening polymerization, atom transfer radical polymerization, and emulsion polymerizations.

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Synthesis of Resins via Multiparallel Suspension Polymerization

Cited by 22 publications

References 5 publications

Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: The Evolution Continues

Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: The Evolution Continues

Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: Past and Present

The fast and the curious: High‐throughput experimentation in synthetic polymer chemistry

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