Synthesis of RGD-peptide modified poly(ester-urethane) urea electrospun nanofibers as a potential application for vascular tissue engineering

Zhu, Tonghe; Yu, Kui; Bhutto, Muhammad Aqeel; Guo, Xuran; Shen, Wei; Wang, Juan; Chen, Wei-Ming; El‐Hamshary, Hany; Al-Deyab, Salem S.; Mo, Xiumei

doi:10.1016/j.cej.2016.12.134

Cited by 84 publications

(39 citation statements)

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“…Initial studies focused on the simplest monoaxial experiment, employing a mixed solution of a polymer and functional component to generate monolithic fibers [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Liu

Yang

et al. 2019

Chemical Engineering Journal

137

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ucture, and in turn its functional performance, is of crucial importance for potential applications. In this study, a new modified triaxial electrospinning process was successfully developed to allow us to precisely tune drug release from nanoscale formulations. In this process, we used two un-electrospinnable liquids as the outer and middle working fluids, with only the core solution being individually electrospinnable into fibers. The outer liquid comprised a mixture of solvents, while the middle fluid was a dilute solution of cellulose acetate (CA). The core fluid was an electrospinnable co-dissolving solution of ferulic acid (FA) and gliadin. By processing these in triaxial electrospinning, we were able to create FA-gliadin fibers coated with a thin but even and continuous coating of CA. The thickness of the CA coating could be precisely varied by adjusting the flow rate of the middle working fluid. The resultant nanofibers have linear and cylindrical morphologies with clear core-shell structures. X-ray diffraction and IR spectroscopy data verified that the fibers comprised amorphous solid dispersions, with intermolecular interactions existing between FA and gliadin. The CA coating eliminated the initial burst release seen with uncoated FA-gliadin fibers, and also led to close to zero-order release profiles which could be incrementally adjusted by varying the thickness of the coating. New process-nanostructure-performance relationships are therefore revealed, and the advanced triaxial electrospinning approach reported in this work has great potential for developing new kinds of functional nanomaterials.

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“…Initial studies focused on the simplest monoaxial experiment, employing a mixed solution of a polymer and functional component to generate monolithic fibers [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Liu

Yang

et al. 2019

Chemical Engineering Journal

137

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“…Furthermore, more collagen deposition and successful cellular apoptosis were observed. Hemocompatibility and biocompatibility analyses revealed that Ac-GRGD-modified PEUU nanofibrous mats had high cytocompatibility against human umbilical vein endothelial cells (HUVECs) and high compatibility with rabbit platelet-rich plasma and red blood cells (Zhu et al, 2017). Zhu et al synthesized poly(ester-urethane) urea nanofibers through an electrospinning technique and modified that with RGDpeptide to provide a novel scaffold with high capability for vascular tissue engineering in 2017.…”

Section: Artificial Neovascularizationmentioning

confidence: 99%

“…Ac-GRGD peptide was immobilized on PEUU nanofibrous mats by covalent coupling to motivate cell adhesion and proliferation. Hemocompatibility and biocompatibility analyses revealed that Ac-GRGD-modified PEUU nanofibrous mats had high cytocompatibility against human umbilical vein endothelial cells (HUVECs) and high compatibility with rabbit platelet-rich plasma and red blood cells (Zhu et al, 2017).…”

Section: Artificial Neovascularizationmentioning

confidence: 99%

Recent progress in biomedical applications of RGD‐based ligand: From precise cancer theranostics to biomaterial engineering: A systematic review

Alipour

Baneshi

Hosseinkhani

et al. 2019

J Biomedical Materials Res

118

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Arginine-glycine-aspartic acid (RGD) peptide family is known as the most prominent ligand for extracellular domain of integrin receptors. Specific expression of these receptors in various tissue of human body and tight association of their expression profile with various pathophysiological conditions made these receptors a suitable targeting candidate for several disease diagnosis and treatment as well as regeneration of various organs. For these reasons, various forms of RGD-based integrins ligands have been greatly used in biomedical studies. Here, we summarized the last decade application progress of RGD for cancer theranostics, control of inflammation, thrombosis inhibition and critically discussed the effect of RGD peptides structure and sequence on the efficacy of gene/drug delivery systems in preclinical studies. Furthermore, we will show recent advances in application of RGD functionalized biomaterials for various tissue regenerations including cornea repair, artificial neovascularization and bone tissue regeneration.Finally, we analyzed clinically translatability of RGD peptides, considering examples of integrin ligands in clinical trials. In conclusion, prospects on using RGD peptide for precise drug delivery and biomaterial engineering are well discussed.

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“…MTT assay and SEM observation were employed to separately evaluate the viability and morphology of the adhered and proliferated L929 cells cultured onto different scaffolds (n=3 for each group) according to the manufacturer's protocol of our previous research. 26 On a separate set of sheets, the attached cells were fixed with 4% paraformaldehyde and then 4′,6′-diamidino-2-phenylindole hydrochloride (DAPI, Invitrogen, USA) and fluorescein isothiocyanate-conjugated phalloidin (Invitrogen, USA) were used to stain the nucleus and cytoskeletons of cells. Specimens were observed under a TS100 fluorescence microscope (Nikon, Japan).…”

Section: Cell Culture and Cytocompatibility Evaluationmentioning

confidence: 99%

<p>Regulating Preparation Of Functional Alginate-Chitosan Three-Dimensional Scaffold For Skin Tissue Engineering</p>

Zhu¹,

Jiang²,

Zhao³

et al. 2019

IJN

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In this study, we attempted to regulate the preparation of Alg-CS-Flu three-dimensional scaffolds via a facile freeze-drying method combined with amidation. Materials and methods: Three-dimensional porous flurbiprofen-grafted alginate (Alg)chitosan (CS) scaffolds were successfully prepared by a facile freeze-drying method combined with amidation for skin tissue engineering applications. Alg-CS composite was first used to load flurbiprofen (Flu), which is a kind of anti-inflammatory non-steroidal molecule. The Flu-loaded Alg/CS composite solution, through freeze-drying and 1-ethyl-3(3-(dimethylamino)propyl) carbodiimide/N-hydroxysuccinimide crosslinking to form an Alg-CS-Flu scaffold, exhibited a uniform and porous morphology that was characterized using scanning electron microscopy. The Alg-CS-Flu as-prepared scaffold was also characterized using Fourier-transform infrared spectroscopy, water contact angle, thermal properties, and stress-strain testing. Results: The results reveal that Flu was successfully grafted onto the surfaces of the Alg-CS-Flu scaffold, which showed good hydrophilicity and appropriate mechanical properties. Furthermore, cell viability, cell morphology from cells cultured in vitro, and hematoxylineosin staining after the graft was subcutaneously embedded in mice for 7 d demonstrated that the Alg-CS-Flu scaffold had no unfavorable effects on the adhesion and proliferation of fibroblasts, as well as a good anti-inflammatory property. Conclusion: The developed Alg-CS-Flu scaffold is proposed as a promising material or skin tissue engineering application.

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Synthesis of RGD-peptide modified poly(ester-urethane) urea electrospun nanofibers as a potential application for vascular tissue engineering

Cited by 84 publications

References 50 publications

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Recent progress in biomedical applications of RGD‐based ligand: From precise cancer theranostics to biomaterial engineering: A systematic review

<p>Regulating Preparation Of Functional Alginate-Chitosan Three-Dimensional Scaffold For Skin Tissue Engineering</p>

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