Synthesis of Schiff Base (E)-2-(((3-Hydroxyphenyl)imino)methyl)-6-methoxyphenol Containing N and O Donors and its Metal Complexes: Spectral, Thermal, Redox Behaviour, Fluorescence Quenching, Antimicrobial and Anticancer Studies

Valarmathy, G.; Subbalakshmi, R.; Renganathan, R.; Kokila, R.

doi:10.14233/ajchem.2018.21085

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…The IR spectra of the complexes are compared with that of the free ligand to determine the changes that might have taken place during the Complexation ( 34,35), all data are listed in table (3).…”

Section: Fig(2): 1 H-nmr Spectrum Of the Ligand (4cl-dibm)mentioning

confidence: 99%

Synthesis and Spectral identifications of new azo – Schiff base ligand(4Cl-2DIBP) derived from (para-aminobenzylamine) with its some metallic complexes

Wafaa Jumaah Imran,

Ibtihal Kadhim Kareem,

Ruba Riyadh Jaafar

2023

J. K. Chem. Sci.

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The New Heterocyclic ligand 4-chloro-2-(((4-((4,5-diphenyl-1H-imidazol-2-yl) diazenyl ) benzyl)imino)methyl) phenol (4Cl-2DIBP) was prepared from the condensation of para-aminobenzylamine with 4,5-diphenyl imidazole, followed by the condensation of the resulting compound with 5- chloro-2- hydroxy benzaldehyde. Different analytical and characterization techniques including (Mass,1HNMR, FT-IR and UV-Vis. spectroscopy and C.H.N elemental analysis) in the investigation of Newly prepared ligand. A series of Novel solid metal complexes of this ligand with Co (II), Ni (II), Cu (II), Zn ((II), Cd (II), and Hg (II) were prepared and all complexes were characterization by techniques above, excluding the Mass and the 1H-NMR spectroscopy of some prepared solid metal complexes and the use of flame atomic absorption spectroscopy to determine the percentages of metal ions in the prepared complexes also studied the magnetic susceptibility and molar conductivity of the metal complexes dissolved in DMSO at 1 × 10-3 M concentration laboratory temperature. The results of this studies showed that the coordination sites for the new Azo-Schiff base ligand with Co (II), Ni (II), Cu (II), Zn ((II) , Cd (II) and Hg(II) were to be through nitrogen of the imidazole ring, and the nitrogen of azo group,. The Electronic spectral and magnetic measurement data predict octahedral structure of the complexes. All complexes showed that Non-electrolytes properties.

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Section: Fig(2): 1 H-nmr Spectrum Of the Ligand (4cl-dibm)mentioning

confidence: 99%

Synthesis and Spectral identifications of new azo – Schiff base ligand(4Cl-2DIBP) derived from (para-aminobenzylamine) with its some metallic complexes

Wafaa Jumaah Imran,

Ibtihal Kadhim Kareem,

Ruba Riyadh Jaafar

2023

J. K. Chem. Sci.

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“…Thus, in the 1 HNMR spectra of free ligand (8) and Zn(II) complex were recorded in DMSO-d 6 as a solvent with TMS as internal standard. The amine proton of Naphthyl ring moiety appeared as singlet signal at δ~ 4.7 ppm [17]. It was shifted to δ= 5.1 ppm in the complex of Zn(II) on moving from the down-field to the up-field region of the 1 H NMR spectrum [18].The multiple signals in the region between δ=7.1-8.0 ppm belong to the aromatic protons [19], while the methylene group (-CH 2 ) appeared at 1.89 ppm .…”

Section: Hnmr Spectramentioning

confidence: 99%

Synthesis and Characterization of Some Transition Metal Complexes with New Azo- Schiff Base Ligand 3,4-bis(((1E,2E)-2-((2-((4-((Z)-(3-Hydroxyphenyl)Diazenyl)Naphthalen-1-yl)amino)ethyl)imino)-1,2-Diphenylethylidene)Amino)Phenyl)(phenyl)Methanone

Kareem

Hadi

2020

Egypt. J. Chem.

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A NEW Azo-Schiff base derivative (3,4-bis(((1E,2E)-2-((2-((4-((Z)-(3-hydroxyphenyl) diazenyl)naphthalen-1-yl)amino)ethyl)imino)-1,2-diphenylethylidene)amino)phenyl) (phenyl)methanone (HANPH) and its metal complexes which include Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Pt(II), and Au(III) metal ions were synthesized. The structure of these compounds has been investigated by using elemental analysis, FT-IR, UV-Vis spectrometric methods, 1 H-NMR, mass spectra, atomic absorption, molar conductivity and magnetic susceptibility of metal complexes. The spectroscopic data of the complexes suggest that their (1:1) (metal: ligand) is mole ratio. Also, the analytical studies for all new complexes have shown octahedral geometries, except for Pt (II) and Au (III) complexes which suggested square planar geometries also its conductivity measurements show electrical properties. These complexes show high conductance value supporting (1:1) electrolytic nature. Furthermore, the FTIR results show that the coordination site from the ligand to the metal ions were through the nitrogen of azomethine group and the nitrogen of the azo group for all new complexes, except for Pt (II) and Au (III) complexes which were through the nitrogen of imine groups only.

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“…Azo-imine ligands containing imidazole groups and their metal complexes have established remarkable attention in the past few years, not only because of their spectroscopic characters and applications but also their pharmacological as well as the electrochemical, stereochemical [1][2], and biological [3] effects. The properties of these type of heterogeneous compounds are due to their containing of imine (C=N) group that resulted from the reaction between primary amines with carbonyl compounds by releasing H 2 O [4][5]. As far as the azo compounds containing -N=N-link in their composition, these compounds are used as bright synthetic colorants and applied in diverse fields such as drug and rust inhibitors and anti-corrosion, such as coating metal surfaces and spoons [6][7].…”

Section: ■ Introductionmentioning

confidence: 99%

Exploring the Anticancer Activity of Gold Complex with Newly Ligand (DDIBM): Synthesis, Spectral Identification and Magnetic Susceptibility of Its Metallic Complexes

Noor,

Kareem

2024

Indones. J. Chem.

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The new heterocyclic ligand, 5-(dimethylamino)-2-(((2-((E)-(4,5-diphenyl-1H-imidazol-2-yl)diazenyl)benzyl)imino)methyl)phenol (DDIBM), was synthesized via the condensation of p-aminobenzylamine with 4,5-diphenyl imidazole, and the resultant compound was condensed with 4-(dimethylamino)-2-hydroxybenzaldehyde. Various instrumental techniques such as mass, 1H-NMR, IR, C.H.N elemental analysis, and UV-vis spectroscopy were used to analyze a newly synthesized ligand. A novel series of complexes was prepared by complexing the ligand with Ni(II), Cu(II), Co(II), and Au(III) and characterized using some of the mentioned techniques. Flame atomic absorption spectroscopy was used to measure the metal ion percentages in the complexes. The magnetic susceptibility and molar conductivity were studied. The electronic spectral data and the magnetic measurement predict the octahedral structure of the complexes except Au(III) complex which has square planer geometry. All complexes showed electrolyte properties. This study aimed to conduct an in vitro cytotoxicity comparative study of DDIBM and its Au(III) complex on human breast cancer cells (MCF-7) and other normal cells. The Au(III) complex was found to be highly selective in targeting cancer cells without affecting normal healthy cells, compared to the ligand. Thus, this complex can be considered as a new drug for treating breast cancer cells (MCF-7), and an attempt in the future to study its effect on other types of cancer.

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Synthesis of Schiff Base (E)-2-(((3-Hydroxyphenyl)imino)methyl)-6-methoxyphenol Containing N and O Donors and its Metal Complexes: Spectral, Thermal, Redox Behaviour, Fluorescence Quenching, Antimicrobial and Anticancer Studies

Cited by 7 publications

References 17 publications

Synthesis and Spectral identifications of new azo – Schiff base ligand(4Cl-2DIBP) derived from (para-aminobenzylamine) with its some metallic complexes

Synthesis and Spectral identifications of new azo – Schiff base ligand(4Cl-2DIBP) derived from (para-aminobenzylamine) with its some metallic complexes

Synthesis and Characterization of Some Transition Metal Complexes with New Azo- Schiff Base Ligand 3,4-bis(((1E,2E)-2-((2-((4-((Z)-(3-Hydroxyphenyl)Diazenyl)Naphthalen-1-yl)amino)ethyl)imino)-1,2-Diphenylethylidene)Amino)Phenyl)(phenyl)Methanone

Exploring the Anticancer Activity of Gold Complex with Newly Ligand (DDIBM): Synthesis, Spectral Identification and Magnetic Susceptibility of Its Metallic Complexes

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