Synthesis of pH‐sensitive grafted psyllium: Encapsulation of quercetin for colon cancer treatment

Abstract

The pH-sensitive polymeric materials are the current need of time in targeted drug delivery applications. The pH-sensitive cross-linked psyllium grafted-poly (acrylonitrile-co-acrylic acid) [Psy-g-Poly (An-co-AA)] was synthesized by using ceric ammonium nitrate (CAN) redox initiator via chemical grafting process for colon cancer treatment. The synthesized material [Psy-g-Poly (An-co-AA)] was characterized by nuclear magnetic resonance, Fourier transform infrared, scanning electron microscopy, X-ray diffraction Zeta potential, and thermal gravimetric analysis. Furthermore, quercetin (QPN) drug was encapsulated in cross-linked grafted psyllium preparing nanoparticles of encapsulated QPN via the sonication technique for controlled release of QPN and testing of in vitro anticancer and antioxidant activities. The anticancer activity of QNP and QPN were studied on human cell line (HCT-15) and it was observed that QNP also exhibited excellent anticancer and antioxidant activity as compared to only QPN. QNP showed maximal swelling at pH-7 and demonstrated maximum QPN release (93%) at the pH of the intestinal fluid (pH-7.4). The drug release kinetic data followed the Korsmeyer-Peppas model (R 2 = 0.9808) kinetic model, indicating the mechanism of drug release from QNP was non-Fickian diffusion. Furthermore, pH-specific QPN release behavior of Psy-g-Poly (An-co-AA) can be utilized for colon targeted drug delivery.

Synthesis and application of polyethyleneimine and polyethylene glycol grafted on CoFe2O4/single‐walled carbon nanotubes as a delivery platform for silibinin: Loading experiments, modeling, and in‐vitro release studies

“…The accumulated amount of SB released into the solution was measured using an Ultraviolet–visible spectrophotometer at of SB (288 nm). The total released mass ( M t ) at the time t was calculated by the following Equation () 25 where is the concentration of released SB at the time t , V is the total volume of release solution, and represents the amount of sample that was taken in each measurement.…”

Unveiling the potential of linseed mucilage, its health benefits, and applications in food packaging

“…The cytotoxicity of QUR@AA-g-FGS was investigated on HCT-15 cell line (cancerous human cell line) and, QUR@AA-g-FGS demonstrated outstanding toxicity toward HCT-15 cell line (95) Seventeen participants in a double-randomized crossover research were given three distinct isocaloric diets high in linseed fiber. The impact on fat, energy excretion, and appetite sensation were measured.…”