Synthesis of self-assembled hyaluronan based nanoparticles and their applications in targeted imaging and therapy

Liu, Kunli; Huang, Xuefei

doi:10.1016/j.carres.2022.108500

Cited by 13 publications

(4 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hyaluronate-based nanoparticles represent a forefront innovation in targeted cancer therapy, harnessing the natural affinity of hyaluronate, a biocompatible and biodegradable polysaccharide, towards CD44 receptors, which are overexpressed in many cancer cells including osteosarcoma [ 131 , 132 , 133 ]. When engineered into nanoparticles, hyaluronate can serve as an effective vehicle for drug delivery, capable of encapsulating a wide array of anti-cancer agents.…”

Section: Resultsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Luo,

Sun,

Tan

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Osteosarcoma, a predominant malignant bone tumor, poses significant challenges due to its high metastatic and recurrent nature. Although various therapeutic strategies are currently in use, they often inadequately target osteosarcoma metastasis. This review focuses on the potential of nanoscale drug delivery systems to bridge this clinical gap. It begins with an overview of the molecular mechanisms underlying metastatic osteosarcoma, highlighting the limitations of existing treatments. The review then transitions to an in-depth examination of nanoscale drug delivery technologies, emphasizing their potential to enhance drug bioavailability and reduce systemic toxicity. Central to this review is a discussion of recent advancements in utilizing nanotechnology for the potential intervention of metastatic osteosarcoma, with a critical analysis of several preclinical studies. This review aims to provide insights into the potential applications of nanotechnology in metastatic osteosarcoma therapy, setting the stage for future clinical breakthroughs and innovative cancer treatments.

show abstract

Section: Resultsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Luo,

Sun,

Tan

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…[37] In contrast, tumor-derived cells often express CD44 in its high-affinity state capable of constitutively binding HA, [38] and the high affinity CD44 is found over-expressed on the surfaces of a wide range of cancer cells. [39][40][41][42] HA has been conjugated to a variety of NPs for imaging applications such as magnetic resonance imaging and fluorescence [43][44][45][46] or in vitro enzyme detection. [47] However, to the best of our knowledge, it has not been utilized for in vivo SERS-NP based detection.…”

Section: Ligand Attachment To Sers-npsmentioning

confidence: 99%

Robust Synthesis of Targeting Glyco‐Nanoparticles for Surface Enhanced Resonance Raman Based Image‐Guided Tumor Surgery

Liu,

Ullah,

Juhong

et al. 2024

Small Science

Self Cite

View full text Add to dashboard Cite

Surface enhanced resonance Raman (SERS) is a powerful optical technique, which can help enhance the sensitivity of Raman spectroscopy aided by noble metal nanoparticles (NPs). However, current SERS‐NPs are often suboptimal, which can aggregate under physiological conditions with much reduced SERS enhancement. Herein, a robust one‐pot method has been developed to synthesize SERS‐NPs with more uniform core diameters of 50 nm, which is applicable to both non‐resonant and resonant Raman dyes. The resulting SERS‐NPs are colloidally stable and bright, enabling NP detection with low‐femtomolar sensitivity. An algorithm has been established, which can accurately unmix multiple types of SERS‐NPs enabling potential multiplex detection. Furthermore, a new liposome‐based approach has been developed to install a targeting carbohydrate ligand, i.e., hyaluronan, onto the SERS‐NPs bestowing significantly enhanced binding affinity to its biological receptor CD44 overexpressed on tumor cell surface. The liposomal hyaluronan (HA)‐SERS‐NPs enabled visualization of spontaneously developed breast cancer in mice in real time guiding complete surgical removal of the tumor, highlighting the translational potential of these new glyco‐SERS‐NPs.

show abstract

“…Hyaluronic acid is an anionic polysaccharide, a glycosaminoglycan, consisting of disaccharide repeating units of β-1,4-D-glucuronic acid-β-1,3-N-acetyl-D-glucosamine. It has a high binding affinity towards the CD44 receptor, highly expressed in cancer cells (Liu and Huang, 2022). It can be used as shell in oil-based NPs, by the solvent displacement technique.…”

Section: Polysaccharide Nanoparticlesmentioning

confidence: 99%

Nanomedical research and development in Spain: improving the treatment of diseases from the nanoscale

Fernández-Gómez

Aranda

Tosat‐Bitrián

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The new and unique possibilities that nanomaterials offer have greatly impacted biomedicine, from the treatment and diagnosis of diseases, to the specific and optimized delivery of therapeutic agents. Technological advances in the synthesis, characterization, standardization, and therapeutic performance of nanoparticles have enabled the approval of several nanomedicines and novel applications. Discoveries continue to rise exponentially in all disease areas, from cancer to neurodegenerative diseases. In Spain, there is a substantial net of researchers involved in the development of nanodiagnostics and nanomedicines. In this review, we summarize the state of the art of nanotechnology, focusing on nanoparticles, for the treatment of diseases in Spain (2017–2022), and give a perspective on the future trends and direction that nanomedicine research is taking.

show abstract

Synthesis of self-assembled hyaluronan based nanoparticles and their applications in targeted imaging and therapy

Cited by 13 publications

References 120 publications

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Robust Synthesis of Targeting Glyco‐Nanoparticles for Surface Enhanced Resonance Raman Based Image‐Guided Tumor Surgery

Nanomedical research and development in Spain: improving the treatment of diseases from the nanoscale

Contact Info

Product

Resources

About