Synthesis of several 2‐carbaldehyde derivatives of quinoline and 1,4‐dihydroquinoline

Abstract

Quinolines represent a versatile class of compounds known for their antimalarial potential. The quinoline derivatives are the class of truly ubiquitous structures involved in the regulation of a wide variety of biological processes. In this paper, several quinoline‐2‐carbaldehyde and 1,4‐dihydroquinoline‐2‐carbaldehyde derivatives were synthesized via Riley reaction. These valuable organic compounds are unique precursors for the synthesis of new plinabulin and new heterocyclic compounds containing ring system of quinolines.

Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties

“…13,14 Promising quinoline-2-carbaldehyde and 1,4-dihydroquinoline-2-carbal dehyde derivatives previously reported in another study were applied in this work. 15 4-Methoxybenzene and 4-chlorobenzene, 2 of the most prevalent substructures in anticancer molecules as scanned against the National Cancer Institute's 60 human tumor cell lines, were also utilized. 16 The successful synthesis of these derivatives offers useful information for the development of more potent VDAs based on plinabulin.…”