2024
DOI: 10.1002/bkcs.12893
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Synthesis of sildenafil and its derivatives bearing pyrazolo‐pyrimidinones scaffold

Seung Su Lee,
Chang Ho Oh

Abstract: The pyrazole ring structure is extensively spotted as a pharmacophore and fortify‐cation of the modern organic synthesis toolbox, which demands synthetic tactics to generate its derivatives. Especially, pyrazolo‐pyrimidinones are crucial part to synthesize phosphodiesterase type 5 (PDE5) such as sildenafil and lodenafil. Herein, we report a simple and efficient route for Sildenafil and derivatives from easily available materials.

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