Synthesis of silicate glass/poly(l-lactide) composite scaffolds by freeze-extraction technique: Characterization and in vitro bioactivity evaluation

El-Kady, Abeer M.; Saad, E. A.; El‐Hady, Bothaina M. Abd; Farag, Mohammad M.

doi:10.1016/j.ceramint.2009.11.012

Cited by 46 publications

(45 citation statements)

References 41 publications

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“…It was noticed that as the glass content increased in the scaffolds, their porosities% decreased considerably. Other studies reported the same conclusion [4,5,19].…”

Section: Measurement Of the Porosity% Of The Scaffoldssupporting

confidence: 53%

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Characterization, and antibacterial properties of novel silver releasing nanocomposite scaffolds fabricated by the gas foaming/salt-leaching technique

El-Kady

Rizk

El‐Hady³

et al. 2012

Journal of Genetic Engineering and Biotechnology

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The main aim of the work was the fabrication of novel silver releasing nanocomposite scaffolds, for bone treatment, by the gas foaming/particulate-leaching technique. Silver doped bioactive glass nanoparticles were used as a filler, to provide the scaffolds with bioactivity, as well as anti-bacterial properties. Nanocomposite scaffolds containing 0, 20 and 40 wt% glass contents were prepared and coded as PAg0, PAg20 and PAg40, respectively. The scaffolds were characterized by SEM/EDXA, FTIR and TGA. Examination of SEM microphotographs showed that, the produced scaffolds had well interconnected structures. For PAg0, PAg20 and PAg40, the maximum pore sizes were about 250, 150 and 100 lm, respectively, while their porosities % were 92%, 89% and 83%, respectively. Degradation studies were carried out, by incubating the scaffolds in simulated body fluid, for a month. Results revealed the possibility to modulate and improve the degradation of the scaffolds by increasing their glass contents. The final weight losses measured for PAg0, PAg20 and PAg40 were 12.76%, 14.61% and 17.42%, respectively. On the other hand, the highest water absorption values recorded for those scaffolds were 61.89%, 240.36% and 270.87%, respectively, indicating that, the addition of glass nanoparticles to the scaffolds improved their water absorption abilities. Both PAg20 and PAg40 induced an apatite layer on their surfaces, had

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“…It was noticed that as the glass content increased in the scaffolds, their porosities% decreased considerably. Other studies reported the same conclusion [4,5,19].…”

Section: Measurement Of the Porosity% Of The Scaffoldssupporting

confidence: 53%

“…2 shows the FTIR spectra of nanocomposite scaffolds (PAg20 and PAg40). All the characteristic peaks, previously reported for the poly (L-lactide), were located in their FTIR spectrum [4,5]. A peak was observed in the range of 1600-1750 cm À1 , which was assigned to the C‚O group vibration.…”

Section: Statistics Analysismentioning

confidence: 99%

Characterization, and antibacterial properties of novel silver releasing nanocomposite scaffolds fabricated by the gas foaming/salt-leaching technique

El-Kady

Rizk

El‐Hady³

et al. 2012

Journal of Genetic Engineering and Biotechnology

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“…The results clearly show the differences in kinetics of calcium phosphate layer formation on the surfaces of composite films depending on the content (12 and 21 vol%) and the chemical composition (A2 and S2) of bioactive glasses. Dependence between in vitro bioactivity and the content of bioactive glass particles in polymer matrix of composite scaffolds was previously reported [39,40]. In our previous works, we have shown that calcium phosphate layer forming ability depends on chemical composition of bioactive glasses [41,42] and also on their particle size [25,26].…”

Section: In Vitro Bioactivitymentioning

confidence: 99%

A new insight into in vitro behaviour of poly(ε-caprolactone)/bioactive glass composites in biologically related fluids

et al. 2017

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In the present work, the role of content, size and chemical composition of gel-derived bioactive glass particles from the SiO 2 -CaO-P 2 O 5 system in modulating the in vitro bioactivity, osteoinductive properties and long-term (up to 15 months) degradation behaviour of poly(e-caprolactone)-based composite films was investigated. Bioactivity was assessed in simulated body fluid (SBF) and HEPES-free Dulbecco's modified Eagle medium (DMEM) supplemented with 10% foetal bovine serum (FBS), while hydrolytic degradation tests were performed in phosphate buffer saline. Obtained composite films showed excellent calcium phosphate (CaP) layer forming ability in both SBF and DMEM-10% FBS. However, kinetics of bioactivity process strongly depended on the type of medium used. The layer of amino acids and proteins, derived from cell culture medium, on the surfaces of composites created barrier that inhibited release of the ions on the one hand, while increasing nucleation density of calcium phosphates, affecting the morphology of formed CaP layers on the other. The presence of bioactive glass fillers was shown to impart osteoinductive properties to obtained films, supporting osteoblast attachment and proliferation, as well as stimulating cell differentiation and also matrix mineralization process in vitro. We showed that kinetics of bioactivity process and also osteoinductive properties of composite films could be easily modulated with the use of different contents and chemical compositions of fillers. The results showed that modification of PCL matrix with bioactive glass particles accelerated its degradation. We proved that the degradation rate of composites could be controlled and optimized for bone regeneration, in particular by using bioactive fillers causing different calcium phosphate layer forming ability on the surfaces of composites, depending on particle size and chemical composition. We have presented new opportunities to design and obtain multifunctional composites with tunable degradation and bioactivity kinetics, as well as biological properties that can meet complex requirements of bone tissue engineering.

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“…Freeze gelation is advantageous over freeze drying as it provides freedom in the choice of solvent, it is time and energy efficient, and can be used on a large scale [5,6]. Various synthetic and natural polymers like chitosan, alginate, poly lactide glycolic acid (PLGA) and carboxy methyl cellulose (CMC) have been used for fabrication of freeze gelled scaffolds in the recent past for tissue engineering applications like controlled drug delivery [5][6][7][8][9]. The scaffolds should have suitable properties such as interconnecting network of pores for the effective migration, growth and attachment of cells, sufficient porosity for the effective transport of nutrients and waste, biocompatibility, suitable mechanical strength, and biodegradation properties, for being exploited in tissue engineering applications [10].…”

Section: Introductionmentioning

confidence: 99%

Freeze-gelled silk fibroin protein scaffolds for potential applications in soft tissue engineering

Bhardwaj

Chakraborty

Kundu

2011

International Journal of Biological Macromolecules

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Synthesis of silicate glass/poly(l-lactide) composite scaffolds by freeze-extraction technique: Characterization and in vitro bioactivity evaluation

Cited by 46 publications

References 41 publications

Characterization, and antibacterial properties of novel silver releasing nanocomposite scaffolds fabricated by the gas foaming/salt-leaching technique

Characterization, and antibacterial properties of novel silver releasing nanocomposite scaffolds fabricated by the gas foaming/salt-leaching technique

A new insight into in vitro behaviour of poly(ε-caprolactone)/bioactive glass composites in biologically related fluids

Freeze-gelled silk fibroin protein scaffolds for potential applications in soft tissue engineering

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