Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents

Abstract

INTRODUCTIONCoronary heart desease (CHD) remains the leading cause of death in the industrialized countries. The primary cause of CHD is athemsclemsis, a disease characterized by the deposition of lipids in the artedal vessel wall, resulting in a narrowing of the vessel passages and ultimately hardening the vascular system. Atherosclerosis as manifested in its major clinical complication, ischaemic heart disease, is thought to begin with local injury to the arterial endothelium followed by proliferation of artedal smooth muscle cells from the medial layer to the intJmal layer along with deposition of lipid and

In vitro anti-leishmanial activities of germatranyl and Silicon incorporated diorganotin derivatives: Synthesis and spectroscopic properties

“…The compounds (1)(2)(3)(4)(5)(6)(7)(8) are quite stable in moist-air and their physico-analytical data are presented in Table I. The molecular structures of the synthesized compounds were established on the basis of the data obtained by elemental analyses and spectroscopic studies like multinuclear ( 1 H, 13 Table II.…”

“…For figure and more details see elsewhere [19]. The CH 2 group of benzyl moiety resonated at 2.5 ppm as a singlet for compounds (5)(6)(7)(8). Phenyl group of the benzyl moiety and phenyl attached to germanium overlap in aromatic region and pose some difficulty to be differentiated.…”

“…Organotin carboxylates are the most ubiquitous owing to their important biocidal activity [3,4]. Toxicological and pharmaco-kinetic studies of germanium revealed its low mammalian toxicity, after these informations, developments were oriented towards its biological applications as chemotherapeutic agents [5][6][7]. Germatranes have been examined for their neurotropic, antitumour, and radioprotective properties [8].…”

Synthesis and cytotoxicity of silylalkylthio‐substituted N‐heterocycles and their hydroselenites

“…Preparation of silylalkylthio-substituted N-heterocycles (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) 10,11 Finely powdered dry K 2 CO 3 (25 mmol, 3.5 g) was added to a solution of 10 mmol of the thiol (1 or 6), 10 mmol of corresponding silyl-substituted alkyl iodide and 18-crown-6 (1 mmol, 264 mg) in 25 ml of toluene. The mixture was refluxed with stirring to achieve the disappearance of the substrates (gas chromatography control), filtered over the thin silica gel layer and concentrated under reduced pressure.…”

Synthesis of 9-Substituted Derivatives of tert-Butyl 6-(9h-Purin-6-Ylthio) Hexylcarbamate

“…6-mercapto purine is used therapeutically as an immunosuppressive agent [6] and inhibits the growth of bacterial and mammalian cells [7]. Other 6-mercapto purine, mercapto pyridine and mercapto pyrimidine derivatives also exhibit antibacterial activity, and have been studied as agents for targeting melanoma [8], reducing cholesterol and as vasodilators [9]. As part of our present research work we are preparing acylated derivatives of tertbutyl 6-(9H-purin-6-ylthio) hexylcarbamate.…”