2013
DOI: 10.1002/adma.201304244
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Synthesis of Silk Fibroin Micro‐ and Submicron Spheres Using a Co‐Flow Capillary Device

Abstract: A custom-made co-flow capillary device is used to synthesize monodisperse silk fibroin micro- and submicron-spheres with diameters tunable over a wide range of sizes. A model drug release is examined and control of degradation kinetics is obtained by changing sphere diameter.

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Cited by 72 publications
(57 citation statements)
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“…A detailed understanding of the phase transition process that results in fiber formation is not only of great academic interest, but also provides key information for any successful attempt to mimic the exceptional material properties observed in natural silk134567. Many components of fibrillar silk can be chemically re-solubilized; in particular reconstituted silk fibroin (RSF)56, obtained by dissolving spun cocoons, has been used in a wide range of applications 5689101112131415. The widespread use of reconstituted silk feedstocks is largely enabled by the relative ease in which this material can be prepared and stored16.…”
mentioning
confidence: 99%
“…A detailed understanding of the phase transition process that results in fiber formation is not only of great academic interest, but also provides key information for any successful attempt to mimic the exceptional material properties observed in natural silk134567. Many components of fibrillar silk can be chemically re-solubilized; in particular reconstituted silk fibroin (RSF)56, obtained by dissolving spun cocoons, has been used in a wide range of applications 5689101112131415. The widespread use of reconstituted silk feedstocks is largely enabled by the relative ease in which this material can be prepared and stored16.…”
mentioning
confidence: 99%
“…The technique involved an all aqueous processing at room temperature, unlike various other techniques of sphere fabrication which expose the drug or SF to heat, pH extremes or freezing and drying [24]. These conditions not only influence the surface of spheres but may also affect the drug release kinetics [23,24,38]. For the sphere fabrication, calculated amounts of SF, DoX and NDs in aqueous solutions were mixed together and flowed through the inner discrete phase channel at a flow rate of 40 µL/h of a co-flow capillary device.…”
Section: Synthesis Of Spheresmentioning
confidence: 99%
“…The fabrication of NDSX spheres was performed through the already developed co-flow technique [38]. The technique involved an all aqueous processing at room temperature, unlike various other techniques of sphere fabrication which expose the drug or SF to heat, pH extremes or freezing and drying [24].…”
Section: Synthesis Of Spheresmentioning
confidence: 99%
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