Synthesis of silver nanoparticles conjugated with kaempferol and hydrocortisone and an evaluation of their antibacterial effects

Kannanoor, Meghana; Lakshmi, Buddolla Anantha; Kim, Sanghyo

doi:10.1007/s13205-021-02880-y

Cited by 11 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kaempferol (KA) is a polyphenolic flavonoid that can be found in multifarious natural substances, such as grapefruit, gingko, tea, propolis, and so on, and displays various medicinal and biological properties [ 9 ]. Numerous studies have suggested that KA has a wealth of health benefits, including antibacterial [ 10 ], anti-asthmatic [ 11 ], anti-inflammatory [ 12 ], stroke prevention [ 13 ], antioxidant [ 14 ], hypoglycemic [ 15 ], and atherosclerosis preventive [ 16 ]. According to the previous studies, KA is an effective antitumor drug in suppressing migration and invasion, modulating the genome, and promoting apoptosis of NSCLC by regulating various signal transduction cellular pathways [ 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Modified Nanostructured Lipid Carrier for Targeting Delivery of Kaempferol to NSCLC: Preparation, Optimization, Characterization, and Performance Evaluation In Vitro

Liu

Cui

et al. 2022

Molecules

View full text Add to dashboard Cite

Lung cancer seriously threatens the health of human beings, with non-small cell lung cancer (NSCLC) accounting for 80%. Nowadays, the potential position of nano-delivery in treating cancer has been the subject of continuous research. The present research aimed to prepare two molecular weight hyaluronic acid (HA)-modified kaempferol (KA)-loaded nanostructured lipid carriers (HA-KA-NLCs) by the method of melting ultrasonic and electrostatic adsorption, and to assess the antitumor effect of the preparations on A549 cells. The characterization and safety evaluation of the preparations illustrated that they are acceptable for drug delivery for cancer. Subsequently, differential scanning calorimetry (DSC) curve and transmission electron microscopy (TEM) images indicated that the drug was adequately incorporated in the carrier, and the particle appeared as a sphere. Moreover, HA-KA-NLC showed predominant in vitro antitumor effects, inhibiting proliferation, migration, and invasion, promoting apoptosis and increasing cellular uptake of A549 cells. Otherwise, the Western blot assay revealed that preparations could activate epithelial-mesenchymal transition (EMT)-related signaling pathways and modulate the expression of E-cadherin, N-cadherin, and Vimentin in A549 cells. Our present findings demonstrated that HA-KA-NLC could be considered as a secure and effective carrier for targeted tumor delivery and may have potential application prospects in future clinic therapy of NSCLC.

show abstract

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Modified Nanostructured Lipid Carrier for Targeting Delivery of Kaempferol to NSCLC: Preparation, Optimization, Characterization, and Performance Evaluation In Vitro

Liu

Cui

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…Furthermore, Cruz et al [ 10 ] demonstrated that the combination of kaempferol 7-O- β -D-(6″-O-cumaroyl)-glucopyranoside with the amikacin and gentamicin at a concentration of 128 μ g/mL led to synergistic actions against S. aureus and E. coli and significantly diminished the minimum inhibitory concentration (MIC) from 16 to 4 and 88 μ g/mL, respectively. One year later, Kannanoor et al [ 33 ] reported that the silver nanoparticles (AgNPs) conjugated with kaempferol (K-AgNPs) demonstrated a considerable bactericidal activity against various bacterial strains including E. coli , Bacillus subtilis , and S. aureus . They used several experimental approaches, including live/dead bacterial ratio analysis, lactate dehydrogenase, and lipid peroxidation analyses.…”

Section: Discussionmentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus: Docking-Based Virtual Screening and Molecular Dynamics Simulations to Identify Potential Penicillin-Binding Protein 2a Inhibitors from Natural Flavonoids

Masumi

Noormohammadi

Kianisaba

et al. 2022

International Journal of Microbiology

View full text Add to dashboard Cite

Staphylococcus aureus (S. aureus) is responsible for several disorders including skin and soft tissue infections, bacteremia, pulmonary infections, septic arthritis, osteomyelitis, meningitis, gastroenteritis, toxic-shock syndrome, and urinary tract infections. Methicillin-resistant S. aureus (MRSA) contains penicillin-binding protein 2a (SauPBP2a) responsible for catalyzing the peptidoglycan production within the bacterial cell wall. The binding affinity of SauPBP2a to beta-lactam antibiotics is low, and thus, it is necessary to discover new effective SauPBP2a inhibitors to combat mortality and morbidity in patients affected by MRSA. The binding affinity of 46 natural flavonoids to the SauPBP2a active site was examined via molecular docking analysis. The stability of docked poses associated with the top-ranked flavonoids was tested by performing molecular dynamics (MD) in 10 nanoseconds (ns) computer simulations. Kaempferol 3-rutinoside-7-sophoroside and rutin demonstrated a considerable binding affinity to the SauPBP2a active site (Δ G binding < − 11 kcal/mol). Their docked poses were found to be stable for 10 ns MD simulations. Kaempferol 3-rutinoside-7-sophoroside and rutin also exhibited salient binding affinity to the enzyme’s allosteric site. This study suggests that kaempferol 3-rutinoside-7-sophoroside and rutin may be considered as drug candidates for therapeutic aims in several human infections associated with MRSA. Nevertheless, in vitro and in vivo confirmations are warranted.

show abstract

“…The novel research of [ 100 ] on the extract of Astragalus creticus , which, among other compounds, contains kaempferol and kaempferol-7-O-β-D-glucopyranose, proved their efficacy against this pathogen. Finally, the conjugation of kaempferol with silver nanoparticles proved effective against B. subtilis [ 217 ].…”

Section: Kaempferol As An Antibacterial Agentmentioning

confidence: 99%

“…The propolis extracts studied by [ 216 ] were also found to be effective against this pathogen. The combination of kaempferol with silver nanoparticles was also proven to be effective against E. coli [ 217 ]. The phytochemical extracts of [ 218 , 219 ] also proved effective against E. coli .…”

Section: Kaempferol As An Antibacterial Agentmentioning

confidence: 99%

“…Another extract, from the plant B. chinense also proved effective against S. aureus [ 172 ]; the results from the extract of Uapaca heudelotti against S. aureus were also positive [ 212 ]. The combination of kaempferol with Ag nanoparticles was also effective against this pathogen [ 217 ]. A successful result was also obtained by [ 219 ], who studied the effects of the extract of Y. gigantea ; this extract was effective against S. epidermidis too.…”

Section: Kaempferol As An Antibacterial Agentmentioning

confidence: 99%

See 1 more Smart Citation

Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications

Periferakis

Bădărău

et al. 2022

IJMS

118

View full text Add to dashboard Cite

Flavonoids are a category of plant-derived compounds which exhibit a large number of health-related effects. One of the most well-known and studied flavonoids is kaempferol, which can be found in a wide variety of herbs and plant families. Apart from their anticarcinogenic and anti-inflammatory effects, kaempferol and its associated compounds also exhibit antibacterial, antifungal, and antiprotozoal activities. The development of drugs and treatment schemes based on these compounds is becoming increasingly important in the face of emerging resistance of numerous pathogens as well as complex molecular interactions between various drug therapies. In addition, many of the kaempferol-containing plants are used in traditional systems all over the world for centuries to treat numerous conditions. Due to its variety of sources and associated compounds, some molecular mechanisms of kaempferol antimicrobial activity are well known while others are still under analysis. This paper thoroughly documents the vegetal and food sources of kaempferol as well as the most recent and significant studies regarding its antimicrobial applications.

show abstract

Synthesis of silver nanoparticles conjugated with kaempferol and hydrocortisone and an evaluation of their antibacterial effects

Cited by 11 publications

References 18 publications

Hyaluronic Acid Modified Nanostructured Lipid Carrier for Targeting Delivery of Kaempferol to NSCLC: Preparation, Optimization, Characterization, and Performance Evaluation In Vitro

Hyaluronic Acid Modified Nanostructured Lipid Carrier for Targeting Delivery of Kaempferol to NSCLC: Preparation, Optimization, Characterization, and Performance Evaluation In Vitro

Methicillin-Resistant Staphylococcus aureus: Docking-Based Virtual Screening and Molecular Dynamics Simulations to Identify Potential Penicillin-Binding Protein 2a Inhibitors from Natural Flavonoids

Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications

Contact Info

Product

Resources

About