Synthesis of Single Nanometer-Sized Au Nanoparticles Coated with Silica Toward X-Ray Contrast Agent
Takeru Sakamoto,
Noriko Yamauchi,
Takumu Takase
et al.
Abstract:In this study, we proposed a method for fabricating diagnostic imaging nanoparticles composed of Au nanoparticles and silica shells (Au/SiO2). The proposed method consisted of two steps. The first step was the synthesis of Au nanoparticles. In sodium hydroxide (NaOH) solution, hydrogen tetrachloroaurate (III) trihydrate was reduced with tetrakis(hydroxymethyl)phosphonium chloride to synthesize Au nanoparticles with a diameter of 1.7 ± 0.3 nm. The Au nanoparticles were then coated with silica in the following s… Show more
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