Synthesis of single-walled carbon nanotubes functionalized with platinum nanoparticles to sense breast cancer cells in 4T1 model to X-ray radiation

Aghaei, Afsoon; Shaterian, Maryam; Danafar, Hossein; Likozar, Blaž; Šuligoj, Andraž; Gyergyek, Sašo

doi:10.1007/s00604-023-05761-8

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…The MTT assay was used to evaluate the enhancement of X‐ray radiation in vitro by the developed radiosensitizer. As shown in Figure 7a–d, the combination of irradiation with nanoparticle treatment had a good effect on lowering cell viability at all tested concentrations compared to the X‐ray group (4 and 8 Gy) only 40 …”

Section: Resultsmentioning

confidence: 88%

“…As shown in Figure 7a-d, the combination of irradiation with nanoparticle treatment had a good effect on lowering cell viability at all tested concentrations compared to the X-ray group (4 and 8 Gy) only. 40 The effect of this combination in the presence of O-SWCNT-BSA + 8 Gy radiation is 80, 76.20, and 75.32%, respectively in different concentrations. In the next step, the effects of Au nanoparticles were evaluated as an increase in sensitization of cancerous cells to X-rays on cytotoxicity.…”

Section: Eds Analysismentioning

confidence: 96%

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The role of single‐walled carbon nanotubes functionalized with gold to increase radiosensitivity of cancer cells to X‐ray radiation

Aghaei,

Shaterian,

Danafar

et al. 2023

Applied Organom Chemis

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The improvement of high‐Z‐based metallic nanostructures as radiosensitizers with high monolithicity and versatility by superadditive therapeutic track and the good protective effect is considerable, but they are limited by some problems such as nonideal selectivity for the target tissue. In this study, nanosystems were developed to enhance the efficacy of radiotherapy and reduce cancer cell survival based on innovative gold (Au) functionalized oxygen‐single‐walled carbon nanotubes (O‐SWCNTs). We illustrate the use of folic acid (FA) as a targeting agent and bovine serum albumin (BSA) to stabilize the physiological environment and increase durability. The physical and chemical properties of the nanosystems were evaluated using transmission electron microscopy (TEM), selected area electron diffraction (SAED), dynamic light scattering (DLS), zeta potential, X‐ray diffraction (XRD), ultraviolet–visible (UV–Visible), and Fourier transform infrared (FTIR) techniques. Finally, the MTT assay was used to investigate the therapeutic effects of nanoparticles in the 4 T1 mouse breast cancer model in the presence and absence of X‐rays. So, the cancer cells experienced a more effective reduction in survival after receiving O‐SWCNTs‐Au‐BSA‐FA + 8 Gy than O‐SWCNTs‐BSA, Au‐BSA‐FA, and O‐SWCNTs‐Au‐BSA + 8 Gy groups.

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Section: Resultsmentioning

confidence: 88%

Section: Eds Analysismentioning

confidence: 96%

The role of single‐walled carbon nanotubes functionalized with gold to increase radiosensitivity of cancer cells to X‐ray radiation

Aghaei,

Shaterian,

Danafar

et al. 2023

Applied Organom Chemis

Self Cite

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show abstract

“…EDS and elemental mapping information from the created SWCNTs provide strong evidence of the structural and elemental purity of the produced SWCNTs. Recently, 16 stated that SWCNTs functionalized with platinum nanoparticles were used to sense breast cancer cells in the 4 T1 model.…”

Section: Resultsmentioning

confidence: 99%

Functionalized single‐walled carbon nanotubes electrochemical aptasensor for human epidermal growth factor receptor 2 (HER2) breast cancer detection

Alshammari,

Al‐Ayed,

Abdelhalim

et al. 2024

Polymers for Advanced Techs

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In this study, we present a novel functionalized single‐walled carbon nanotubes (SWCNTs) electrochemical aptasensor designed for the detection of HER2 breast cancer. The well‐organized SWCNTs were attained through a concentration‐based and single‐step ultrasonication‐directed assembly methodology, resulting in a well‐dispersed state and a thin, even coating on the transducer substrate. Well‐organized SWCNTs were systematically analyzed through X‐ray diffraction spectroscopy (XRD), Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy and elemental mapping (TEM‐mapping) and X‐ray photoelectron spectroscopy (XPS) confirmed the superior quality and organization of the SWCNTs. Furthermore, the electrochemical sensor exhibited outstanding performance, showcasing the potential of the SWCNTs as an ideal material for such applications, including their anticancer activity against human breast cancer cells. The single‐step ultrasonication‐directed assembly approach not only enhances the electrochemical properties of SWCNT but holds promise as a potentially as versatile substrate for immobilizing enzymes, antibodies, and DNA. This versatility opens up opportunities for the creation of highly functional biosensors with broad medical applications. Overall, our findings highlight the scientific significance of SWCNTs in advancing electrochemical sensing technologies and their potential in combating breast cancer.

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Application of nanoparticles in breast cancer treatment: a systematic review

Bourang,

Noruzpour,

Jahanbakhsh Godekahriz

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Synthesis of single-walled carbon nanotubes functionalized with platinum nanoparticles to sense breast cancer cells in 4T1 model to X-ray radiation

Cited by 3 publications

References 42 publications

The role of single‐walled carbon nanotubes functionalized with gold to increase radiosensitivity of cancer cells to X‐ray radiation

The role of single‐walled carbon nanotubes functionalized with gold to increase radiosensitivity of cancer cells to X‐ray radiation

Functionalized single‐walled carbon nanotubes electrochemical aptasensor for human epidermal growth factor receptor 2 (HER2) breast cancer detection

Application of nanoparticles in breast cancer treatment: a systematic review

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