Synthesis of size-controlled and highly monodispersed silica nanoparticles using a short alkyl-chain fluorinated surfactant

Nagappan, Saravanan; Mohan, Anandhu; Thomas, Andrew M.; Yoo, Jongman; Eid, Nadim; Chung, Ildoo; Améduri, Bruno; Ha, Chang‐Sik

doi:10.1039/d0ra08114k

Cited by 6 publications

(6 citation statements)

References 52 publications

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“…We then initiated the sol–gel process of silica precursor tetramethyl orthosilicate (TMOS) on the surface of the nanoemulsion. In the case of preparing nanoparticles with fluorinated surfactant C10-TAC or C8-TAC, the concentration of surfactant was calculated from CMC and fixed at 1 × CMC ( Nagappan et al, 2021 ). The surfactant was mixed with PAP with optimized ratio of 0.33 mg for the best formation of nanoemulsion ( Supplementary Table S1 ; Supplementary Figure S3 ).…”

Section: Resultsmentioning

confidence: 99%

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Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI

Wu,

Minoshima,

Kikuchi

2024

Front. Chem.

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Perfluorocarbon-encapsulated silica nanoparticles possess attractive features such as biological inertness and favorable colloidal properties for bioimaging with fluorine magnetic resonance imaging (19F MRI). Herein, a series of elliptic shaped silica nanoparticles with perfluorocarbon liquid perfluoro-15-crown-5 ether as core (PFCE@SiO2) were synthesized using fluorinated surfactants N-(perfluorononylmethyl)-N,N,N-trimethylammonium chloride (C10-TAC) and N-(perfluoroheptylmethyl)-N,N,N-trimethylammonium chloride (C8-TAC). The nanoparticles are characterized to obtain elliptic core-shell structures. PFCE@SiO2 showed strong 19F NMR signals of the encapsulated PFCE, indicating the potential as a highly sensitive 19F MRI probe. These elliptic PFCE@SiO2 nanoparticles provide a new option of 19F MRI probe with a morphology different from conventional nanospheres.

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Section: Resultsmentioning

confidence: 99%

“…Fluorinated surfactants can behave as an alternative surfactant for uniform and size-controlled synthesis of silica nanoparticles in conventional methods. Moreover, the size, shape, and dispersibility of the particles can also be tuned by using fluorinated surfactants ( Nagappan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI

Wu,

Minoshima,

Kikuchi

2024

Front. Chem.

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“…Further, Nagappan et al explored the fluorinated surfactants such as perfluoropentanoic acid (PFPA), perfluorohexanoic acid (PFHA) and 3-hydroxy-2-(trifluoromethyl)-propanoic acid (MFA–OH) at 0.5 mmol concentration to yield small-sized silica NPs. The authors found that fluoro-surfactant having short alkyl-chain was more capable in generating monodisperse silica particles of 50–200 nm as compared to long-alkyl chain fluorinated or nonfluorinated surfactant template …”

Section: Mesoporous Silica Nanoparticles (Msn) Synthesis Structure An...mentioning

confidence: 99%

Ordered Mesoporous Silica Delivering siRNA as Cancer Nanotherapeutics: A Comprehensive Review

Gupta,

Choudhury,

Meena

et al. 2024

ACS Biomater. Sci. Eng.

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Nanosized mesoporous silica has emerged as a promising flexible platform delivering siRNA for cancer treatment. This ordered mesoporous nanosized silica provides attractive features of well-defined and tunable porosity, structure, high payload, and multiple functionalizations for targeted delivery and increasing biocompatibility over other polymeric nanocarriers. Moreover, it also overcomes the lacunae associated with traditional administration of drugs. Chemically modified porous silica matrix efficiently entraps siRNA molecules and prevents their enzymatic degradation and premature release. This Review discusses the synthesis of silica using the sol−gel approach and the advantages with different silica mesostructure. Herein, the factors affecting the synthesis of silica at nanometer scale, shape, porosity and nanoparticle surface modification are also highlighted to attain the desired nanostructured silica carriers. Additional emphasis is given to chemically modified silica delivering siRNA, where the silica nanoparticle surface was modified with different chemical moieties such as amine modified with (3-aminoropyl) triethoxysilane, polyethylenimine, chitosan, poly(ethylene glycol), and cyclodextrin polymer modification to attain high therapeutic loading, improved dispersibility and biocompatibility. Upon systemic administration, ordered mesoporous nanosized silica encounters blood cells, immune cells, and organs mainly of the reticuloendothelial system (RES). Thereby, biocompatibility and biodistribution of silica based nanocarriers are deliberated to design principles for smart and efficacious nanostructured silica-siRNA carriers and their clinical trial status. This Review further reports the future scopes and challenges for developing silica nanomaterial as a promising siRNA delivery vehicle demanding FDA approval.

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“…Due to the availability of abundant carboxylic acids and hydroxyl groups, it can increase the bonding of the nanoparticle surface through hydrogen bonds in non-ionic surfactants and weaken the van der walls and electrostatic forces on ionic surfactants. Both mechanisms can induce aggregation at higher surfactant concentrations [30,31]. On the other hand, surfactants can also be used as a template to control the pore size of the silica particles.…”

Section: Introductionmentioning

confidence: 99%

High Surface Area Silica Particles Using Anionic Surfactant Template Prepared by One-step Spray Drying System for Dye Removal Application

Ajiz

Albar

Widiyastuti

et al. 2022

Period. Polytech. Chem. Eng.

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This study reported the effect of sodium lauryl sulfate (SLS) as a template on silica morphology and its properties. The precursor was prepared by producing silica nanofluid by the sol-gel method and mixed with various SLS concentrations. After that, the precursor was spray-dried to generate silica powder. An increase in SLS concentration up to 2 critical micelle concentration (CMC) indicates an increase in the silica particle size from 2.12 μm in untemplated silica particles to 2.58 μm. On the other hand, when the SLS concentration increases to 3 CMC, the particle size decreases to 2.19 μm. A significant increase in total pore volume and surface area is obtained for silica particles synthesized at least at the SLS concentration of 2 CMC, around eight higher volumes than without SLS addition. In addition, they have a macropore compared to silica particles synthesized without SLS addition that only exhibits mesopore. The surface area was 1,011 m2/g for the SLS concentration at 3 CMC, whereas the silica without SLS has only a surface area of 131 m2/g. The SLS concentration at 2 CMC or higher leads to a significant increase in its physical properties because the micelle formation is enough for sacrificed template formation. Methylene blue solution was used as an adsorbate for evaluating the dye adsorption capacity that followed the Langmuir isothermal adsorption model. The highest theoretical maximum monolayer adsorption capacity was 142.9 mg/g, obtained by silica adsorbent with the SLS concentration at 3 CMC.

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Synthesis of size-controlled and highly monodispersed silica nanoparticles using a short alkyl-chain fluorinated surfactant

Abstract: Shape, size, and morphology controlled synthesis of monodispersed silica nanoparticles using 3-hydroxy-2-(trifluoromethyl)-propanoic acid (MAF-OH) surfactant.

Cited by 6 publications

References 52 publications

Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI

Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI

Ordered Mesoporous Silica Delivering siRNA as Cancer Nanotherapeutics: A Comprehensive Review

High Surface Area Silica Particles Using Anionic Surfactant Template Prepared by One-step Spray Drying System for Dye Removal Application

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