Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities

Karakurt, Arzu; Dalkara, Sevim; Özalp, Meral; Özbey, Süheyla; Kendi, Engin; Stables, James P.

doi:10.1016/s0223-5234(01)01223-5

Cited by 123 publications

(84 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, in the light of available literature and as a continuation of our previous studies on anticonvulsant nafimidone derivatives, we aimed to evaluate the effects of some new oxime ester derivatives of nafimidone on disorders of thermal pain sensation in diabetic mice (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effects of Novel Nafimidone Derivatives on Thermal Hypoalgesia in Mice with Diabetic Neuropathy

et al. 2013

Self Cite

View full text Add to dashboard Cite

The worldwide diabetes epidemic has shown no signs of abatement. Its prevalence has more than doubled since 1980 (1). Diabetic neuropathy (DN) is the most common diabetic complication, afflicting over 50% of all diabetics. The possible biochemical pathomechanisms include oxidative stress, activation of the polyol pathway, increased advanced glycation end products (AGEs) and their receptors, impaired ionic homeostasis of cells and activation of protein kinases (PKC and PKA), and mitogen-activated protein kinases (MAPK), and inducible nitric oxide synthase (2-6).Understanding the biochemical mechanisms underlying diabetic neuropathic pain and sensory disorders requires preclinical studies in animal models. The streptozotocin (STZ)-induced diabetic rodent is the most commonly used animal model of diabetes (7,8). On the other hand, existing animal models of diabetic painful and insensate neuropathy, however, have serious limitations. Diabetic rats and mice have limited life span and rarely show evidence of overt neuropathy, such as demyelination, axonal degeneration, fiber loss, or axonal regeneration in their peripheral nerves. This makes diabetic rodents unsuitable for studying the contribution of these phenomena of DN to pain or to loss of sensory function (9). Nonetheless, despite these limitations, assessment of behavioral responses to external stimuli in diabetic rats and mice (i.e., thermal and mechanical hyper and hypoalgesia, tactile allodynia, as well as formalin-induced spontaneous nociceptive behavior) has led to identification of a number of mechanisms of loss of sensation and/or pain in diabetes (10).Decades of research elucidating the pathophysiology of diabetic neuropathy have failed, thus far, to produce a treatment that prevents or reverses its development and progression. Recently, however, numerous competing or parallel pathological pathways have begun to intersect and complement each other, illuminating potential pharmacologic targets. The current foci of diabetic neuropathy research are excessive activation of sodium channels and corrupted molecular mechanisms of cellular pathways of related kinases (11).Voltage-gated sodium channels (Na v Chs) are a necessary component of normal sensation, emotions, thoughts and movements and are of particular interest as target for neuro- ABSTRACTObjective: Diabetic neuropathy (DN) is a common complication in Diabetes Mellitus. The streptozotocin-induced diabetic rodent is the most commonly used animal model of diabetes and increased sodium channel expression and activity were revealed in this model. At this study, we evaluated the effect of three different nafimidone derivatives which have possible anticonvulsant activity on disorders of thermal pain sensation in diabetic mice.Study Design: Randomized animal experiment.Material and Methods: Mice were divided randomly into five groups (5 mice per group): Control, Diabetes, Dibetes+C1, Diabetes+C2, Diabetes+C3. We used hot and cold plate, and tail-immersion tests for assessment of thermal nociceptive response...

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effects of Novel Nafimidone Derivatives on Thermal Hypoalgesia in Mice with Diabetic Neuropathy

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…N-Hydroxy-phthalimide 1 (known also as NHPI), is a commercially available compound that is easily synthesized from phthalic anhydride and hydroxylamine [1] (obtained for the first time by Cohn [2] in 1880). This compound is a weak acid (pK a = 6.1) [3,4] and has a variety of practical uses.…”

Section: Introductionmentioning

confidence: 99%

New N-aryloxy-phthalimide derivatives. Synthesis, physico-chemical properties, and QSPR studies

Tudose¹,

Badea

Cãproiu³

et al. 2010

Open Chemistry

View full text Add to dashboard Cite

Abstract:Starting from N-hydroxyphthalimide 1 and the reactive fluoro-or chloro-nitroaryl derivatives 2, 3 and 4a-e (2-chloro-3,5-dinitropyridine; 3, NBD-chloride; 4a, 1-fluoro-2,4-dinitrobenzene; 4b, picryl chloride; 4c, 4-chloro-3,5-dinitrobenzotrifluoride; 4d, 2-chloro-3,5-dinitrobenzotrifluoride; 4e, 4-chloro-3,5-dinitrobenzoic acid) the corresponding N-(2-nitroaryloxy)-phthalimide derivatives 5a-e, or 6 and 7 were obtained and characterized by IR, UV-Vis 1 H-NMR and 13 C-NMR spectroscopy. The TLC behavior and the hydrophobicity of these derivatives have been experimentally evaluated by R M0 parameters (using RP-TLC). The experimental R M0 parameters were compared with the calculated partition coefficient, log P. A QSPR study was also performed to establish possible correlations between the structure and physical properties (λ max and R M0 ) of compounds 5a-e, 6, and 7.

show abstract

“…In recent years much work has been published on oxime derivatives with different pharmacological properties: for example: anti-tumor [2], anti-microbial, anticonvulsant [3,4], antiarrhythmic, analgesic and anesthetic properties [5,6]. Many oximes also have been studied to investigate their antidepressant activity [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives

et al. 2006

View full text Add to dashboard Cite

show abstract

Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities

Cited by 123 publications

References 12 publications

Evaluation of the Effects of Novel Nafimidone Derivatives on Thermal Hypoalgesia in Mice with Diabetic Neuropathy

Evaluation of the Effects of Novel Nafimidone Derivatives on Thermal Hypoalgesia in Mice with Diabetic Neuropathy

New N-aryloxy-phthalimide derivatives. Synthesis, physico-chemical properties, and QSPR studies

Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives

Contact Info

Product

Resources

About