Synthesis of some 1-aryl-3,5-disubstituted-pyrazoles by N-arylation of 3,5-disubstituted-pyrazoles with 4-fluoro and 2-fluoronitrobenzene under microwave irradiation and classical heating

Bouabdallah, Ibrahim; Touzani, Rachid; Zidane, Ismail; Ramdani, Abdelkrim; Radi, Smaail

doi:10.3998/ark.5550190.0007.c16

Cited by 11 publications

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Divergent Synthesis of 1H‐Indazoles and 1H‐Pyrazoles from Hydrazones via Iodine‐Mediated Intramolecular Aryl and sp³ C–H Amination

et al. 2017

View full text Add to dashboard Cite

A divergent intramolecular C–H amination of hydrazones has been developed employing molecular iodine (I2) as the sole oxidant. The required hydrazone substrates were readily obtained by condensation of hydrazines with the corresponding ketones. In the presence of potassium iodide, I2‐mediated oxidative cyclization of diaryl and tert‐butyl aryl ketone hydrazones produced 1H‐indazoles via direct aryl C–H amination. Under similar reaction conditions, primary and secondary alkyl ketone hydrazones were transformed into 1H‐pyrazole products in a reaction involving sp3 C–H amination. This synthetic methodology does not involve transition metals, and is operationally simple, providing a facile access to indazole and pyrazole derivatives in an efficient and scalable fashion.magnified image

show abstract

Divergent Synthesis of 1H‐Indazoles and 1H‐Pyrazoles from Hydrazones via Iodine‐Mediated Intramolecular Aryl and sp³ C–H Amination

et al. 2017

View full text Add to dashboard Cite

show abstract

The Structure ofN‐phenyl‐pyrazoles and Indazoles: Mononitro, Dinitro, and Trinitro Derivatives

Claramunt

María

Alkorta

et al. 2017

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

show abstract

Ring Functionalization and Molecular Hybridization of Quinolinyl Pyrazole: Design, Synthesis and Antimycobacterial Activity

et al. 2017

View full text Add to dashboard Cite

Synthesis of quinolinyl pyrazole analogues by ring functionalization as well as molecular hybridization strategy is adopted. Diverse functional groups were assembled around the privileged scaffold viz., 2-methyl-3-(1H-pyrazol-5-yl)quinoline. A series of quinolinyl pyrazole analogues with 1,4-disubstituted 1,2,3-triazole moiety, were synthesized employing Click reaction conditions. All 29 synthesized were evaluated for antitubercular activity against Mycobacterium smegmatis strain; wherein eight compounds were active and two promising. Compounds also exhibited the low cytotoxicity against A549 cell line.[a] Dr.

show abstract

Synthesis of some 1-aryl-3,5-disubstituted-pyrazoles by N-arylation of 3,5-disubstituted-pyrazoles with 4-fluoro and 2-fluoronitrobenzene under microwave irradiation and classical heating

Cited by 11 publications

References 7 publications

Divergent Synthesis of 1H‐Indazoles and 1H‐Pyrazoles from Hydrazones via Iodine‐Mediated Intramolecular Aryl and sp³ C–H Amination

Divergent Synthesis of 1H‐Indazoles and 1H‐Pyrazoles from Hydrazones via Iodine‐Mediated Intramolecular Aryl and sp³ C–H Amination

The Structure ofN‐phenyl‐pyrazoles and Indazoles: Mononitro, Dinitro, and Trinitro Derivatives

Ring Functionalization and Molecular Hybridization of Quinolinyl Pyrazole: Design, Synthesis and Antimycobacterial Activity

Contact Info

Product

Resources

About

Synthesis of some 1-aryl-3,5-disubstituted-pyrazoles by N-arylation of 3,5-disubstituted-pyrazoles with 4-fluoro and 2-fluoronitrobenzene under microwave irradiation and classical heating

Cited by 11 publications

References 7 publications

Divergent Synthesis of 1H‐Indazoles and 1H‐Pyrazoles from Hydrazones via Iodine‐Mediated Intramolecular Aryl and sp3 C–H Amination

Divergent Synthesis of 1H‐Indazoles and 1H‐Pyrazoles from Hydrazones via Iodine‐Mediated Intramolecular Aryl and sp3 C–H Amination

The Structure ofN‐phenyl‐pyrazoles and Indazoles: Mononitro, Dinitro, and Trinitro Derivatives

Ring Functionalization and Molecular Hybridization of Quinolinyl Pyrazole: Design, Synthesis and Antimycobacterial Activity

Contact Info

Product

Resources

About

Divergent Synthesis of 1H‐Indazoles and 1H‐Pyrazoles from Hydrazones via Iodine‐Mediated Intramolecular Aryl and sp³ C–H Amination

Divergent Synthesis of 1H‐Indazoles and 1H‐Pyrazoles from Hydrazones via Iodine‐Mediated Intramolecular Aryl and sp³ C–H Amination