Synthesis of Some 3‐(Arylalkylthio)‐4‐alkyl/aryl‐5‐(4‐aminophenyl)‐4H‐1,2,4‐triazole Derivatives and Their Anticonvulsant Activity.

Abstract

Triazole derivatives R 0280Synthesis of Some 3-(Arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole Derivatives and Their Anticonvulsant Activity. -The synthesis of the title triazoles (VI) is aimed at investigating antimicrobial and antimycobacterial properties in addition to their anticonvulsant activities. The primary amino group in (VI) is masked to observe the contribution of this function to pharmacological activity. Protective activities in the maximal electroshock (MES) test as well as in the subcutaneous pentylenetetrazole (sc PTZ) test are shown by triazoles (VIa) and (VIb). The novel triazoles are devoid of antibacterial and antimycobacterial activity. Triazoles (VIc) and (VIII) display marginal activity against M. tuberculosis H37. -(KUECUEKGUEZEL, I.; KUECUEKGUEZEL, G. S.; ROLLAS, S.; OETUEK-SANIS, G.; OEZDEMIR, O.; BAYRAK, I.; ALTUG, T.; STABLES, J. P.; Farmaco 59 (2004) 11, 893-901; Dep. Pharm. Chem., Fac. Pharm., Marmara Univ., Haydarpasa, TR-81010 Istanbul, Turk.; Eng.) -H. Hoennerscheid 12-136

Severe Acute Respiratory Syndrome Coronavirus Replication Inhibitor That Interferes with the Nucleic Acid Unwinding of the Viral Helicase

“…SSYA10-001 is a derivative of the triazole group. Some derivatives of triazole consist of compounds that have been shown to have high bioavailability (55), with some of them demonstrating anti-inflammatory, antimycobacterial, antimicrobial, anticonvulsant, and analgesic activities (1,9,22,26,27,29). Interestingly, a triazole-3-thione compound which is closely related to SSYA10-001 was shown to be a potent antithyroid compound with low toxicity (28).…”

Crystal structure of (E)-N-(4-(dimethylamino)benzylidene)-3-(2,4-dinitrophenylthio)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-4-amine, C24H21N7O5S

“…Af ew (E)-N-benzylidene-3-alkylthio-5-substituted-4H-1,2,4-triazol-4-amines have been reported to exhibit antifungal activity [2,3], antimicrobial properties [4,5], anticonvulsant activity [6], and antitumour effects [7]. It is to be expected that their arylsubstituted analogues (E)-N-benzylidene-3-arylthio-5-substituted-4H-1,2,4-triazol-4-amines can exhibit the superposition of diversiform biological and pharmacological activities because they join aryl (containing heterocyclic radical), imine, thioether and other groups.…”

5-Pentadecyl-2-((p-tolylimino)methyl)phenol

“…Schiff bases derived from various aromatic or heterocycles have been reported to possess cytotoxic [1], anticonvulsant [2], antiproliferative [3], antimicrobial [4], anticancer [5], and antifungal activities [6]. In view of these reports, in the present work we have synthesized the title compound.…”