Synthesis of Some Amino Acid and Peptide Conjugates and their Evaluation as Potential Anti-allergic and Anti-inflammatory Agents

Abstract

NEW series of N-3-(2-furanyl) acryloyl, N-3-(5-methyl)-2-……(furanyl)-acryoyl amino acids, peptide and piprazines amids, were structurally designed and synthesized. About 23 compounds (5aw) were synthesized and their anti-allergic and anti-inflamatory activities were evaluated relative to those of Loratadine (Clorinix ®) and Diclofenac ®. All the obtained products showed good anti-allergic activities with the greatest activities recorded for compounds (5g, 5h, 5j, 5k, 5m, 5n, 5v and 5w). All compounds showed LD 50 with safety margin. On the other hand most compounds have no anti-inflamatory activities except products (5d, 5e and 5p).