Synthesis of Some Coumarinyl Chalcones and their Antiproliferative Activity Against Breast Cancer Cell Lines

Patel, Kuldeep; Karthikeyan, Chandrabose; Solomon, V. Raja; Moorthy, N. S. Hari Narayana; Lee, Hoyun; Sahu, Kapendra; Deora, Girdhar Singh; Trivedi, Piyush

doi:10.2174/157018011794839475

Cited by 39 publications

(38 citation statements)

References 33 publications

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“…Absorbation at 1026 cm -1 from outreach the symmetric C-O-C. Absorbation at 1635 cm -1 characteristic for the carbonyl group (-C=O). The emergence of absorbation at 1118.71 cm -1 indicate the presence of -OCH 3 .…”

Section: Synthesis Of 2'4-dihydroxy-3-methoxychalcone (1)mentioning

confidence: 99%

“…Cancer is the second leading cause of human death after cardiovascular disease worldwide [3]. There is a continuous rise of deaths from various cancer worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…Many different therapeutic strategies are currently available for cancer treatments, including chemotherapy and radiotherapy. However, the high mortality rate indicates that the treatment with chemotherapy has not overcome the cancer because it has systemic toxicity [9] and resistance case [3]. Thus, there is a continuous need for the development of novel anticancer agents for the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of 2’,4-dihydroxy-3-methoxychalcone and 2’,4’,4-trihydroxy-3-methoxychalcone as a candidate anticancer against cervical (WiDr), colon (HeLa), and breast (T47d) cancer cell lines in vitro

Matsjeh¹,

Swasono²,

Anwar³

et al. 2017

AIP Conference Proceedings

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Section: Synthesis Of 2'4-dihydroxy-3-methoxychalcone (1)mentioning

confidence: 99%

“…Cancer is the second leading cause of human death after cardiovascular disease worldwide [3]. There is a continuous rise of deaths from various cancer worldwide.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis of 2’,4-dihydroxy-3-methoxychalcone and 2’,4’,4-trihydroxy-3-methoxychalcone as a candidate anticancer against cervical (WiDr), colon (HeLa), and breast (T47d) cancer cell lines in vitro

Matsjeh¹,

Swasono²,

Anwar³

et al. 2017

AIP Conference Proceedings

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“…A series of coumarinic chalcones 22 were synthesized by Claisen-Schmidt condensation of 1 with various aryl or heteroaryl aldehydes 21 in the presence of piperidine in chloroform (Al-Ayed, 2011;Naceur et al, 2011;Patel et al, 2011), benzene (Lin et al, 2005), ethanol (Abdelhafez et al, 2010;Matos et al, 2013) or acetic acid (Li et al, 2012a,b) (Scheme 15). The presence of coumarin nucleus gives to these species an important pharmacological and therapeutic interest.…”

Section: Condensation With Aldehydesmentioning

confidence: 99%

3-Acetyl-4-hydroxycoumarin: Synthesis, reactions and applications

Abdou

2017

Arabian Journal of Chemistry

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The chemistry of 3-acetyl-4-hydroxycoumarin has gained increased interest in both synthetic organic and biological fields, since a large number of developments in the use of such compound seem to be of considerable value. This review summarizes results from the literature concerning the synthesis and reactions of 3-acetyl-4-hydroxycoumarin as well as its applications are also discussed.ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.

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“…) antioxidant, antibacterial (Hamdi et al, 2010), anti-inflammatory (Sashidhara et al, 2011), antiviral (Trivedi et al, 2007), trypanocidal (Vazquez-Rodriguez et al, 2013), analgesic 4 (Jayashree et al, 2009) and antiproliferative (Patel et al, 2011) activities. Recent research suggests that the fusion of a chalcone moiety with the coumarin ring may be promising for the synthesis of derivatives with enhanced TPA (two-photon absorption) cross-sections .…”

Section: Introductionmentioning

confidence: 99%

A convenient synthesis of coumarinyl chalcones using HClO4–SiO2: A green approach

Siddiqui

2019

Arabian Journal of Chemistry

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Graphical abstractA simple and efficient one-pot synthesis of coumarinyl chalcones was reported in the presence of silica supported perchloric acid under solvent-free heating at 80 °C in excellent yields. The catalyst was recycled for four runs without any loss of its catalytic activity. AbstractHClO 4 -SiO 2 catalysed synthesis of coumarinyl chalcones (8a-j) under solvent-free conditions is reported. The catalyst is characterized by powder XRD and SEM-EDX analysis. The stability of the catalyst is evaluated by thermogravimetric (TG) and differential scanning calorimetry (DSC) techniques. The remarkable features of this green protocol are excellent yields of the products, shorter reaction time, simple experimental procedure, easy preparation and reusability of the catalyst.

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Synthesis of Some Coumarinyl Chalcones and their Antiproliferative Activity Against Breast Cancer Cell Lines

Cited by 39 publications

References 33 publications

Synthesis of 2’,4-dihydroxy-3-methoxychalcone and 2’,4’,4-trihydroxy-3-methoxychalcone as a candidate anticancer against cervical (WiDr), colon (HeLa), and breast (T47d) cancer cell lines in vitro

Synthesis of 2’,4-dihydroxy-3-methoxychalcone and 2’,4’,4-trihydroxy-3-methoxychalcone as a candidate anticancer against cervical (WiDr), colon (HeLa), and breast (T47d) cancer cell lines in vitro

3-Acetyl-4-hydroxycoumarin: Synthesis, reactions and applications

A convenient synthesis of coumarinyl chalcones using HClO4–SiO2: A green approach

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