Synthesis of Some Fully 3′ and 4′-C-Branched-Chain Sugar Nucleoside Analogues

Abstract

The synthesis of some new 3'-azido-3'-C-substituted pyrimidine nucleoside analogues is described. The key step is the geminal disubstitution of an appropriated ketone carbohydrate, via the regioselective ring opening of the corresponding tosyl-epoxide derivative.

Azidonucleosides: Synthesis, Reactions, and Biological Properties

“…There is a brief paper on the synthesis of 3‘- and 4‘-C-branched-chain sugar nucleoside analogues such as 6.054 from the ketoanhydro carbohydrate 6.053 …”