Synthesis of Some Heterocyclic Compounds Derived from Furfural Using Ultrasonic Waves

Abstract

All melting points were uncorrected and measured using Electro thermal melting point apparatus, All chemical were supplied by Aldrich and fluka and BDH companies. Bruker Avance 111 400 MHz was used for 1HNMR measurements. Infrared spectrophotometer model FT (600) CO. LTD (UK) and FT (8400 s) shimadzo were used for IR measurements. power sonic 405 micro process-controlled bench -top ultra-sonic cleaner was used for Ultrasound chemical

Preparation of Furanyl Primary Amines from Biobased Furanyl Derivatives over Heterogeneous Catalysts

“…58 FAM, a nitrogen derivative of furfural, is an emerging molecule with numerous promising applications, including pharmaceuticals and agrochemicals. 80 The size of the FAM market is anticipated to reach USD 1.2 billion by 2028, expanding at a CAGR of 3.5%. 58 Due to the simple hydrogenation of the −CHO group and ring opening reactions, the amination of furfural presents particular challenges.…”

“…Furfural can be produced by acid-catalyzed dehydration of xylose from nonfood biomass, such as bagasse or corn cobs. , As a platform molecule, furfural has found widespread use in the organic synthesis, pharmaceutical, transport fuel, and chemical industries, and it is a potential intermediate in the production of high-value chemicals. , The demand for green chemicals and the expanding industrial applications of various furfural derivatives (e.g., cyclopentanone, dicarboxylic acid, amyl lactone, furfuryl alcohol, tetrahydrofuran, FAM, and glutaryl alcohol) are driving the furfural market . FAM, a nitrogen derivative of furfural, is an emerging molecule with numerous promising applications, including pharmaceuticals and agrochemicals . The size of the FAM market is anticipated to reach USD 1.2 billion by 2028, expanding at a CAGR of 3.5% .…”

Synthesis of Some Diazine and Triaazole Derivatives From Furfural

“…Furfural for example 2-(2-furyl) [1,3] dioxane,5-nito(1,3-imidazolyl-2,5-dion)-3-yl furfurlidine was found to be used for treatment of urinary tract [8][9][10] also furfural derivatives were used for different biological applications [11,12] It was also known that many triazoles and diazines compounds were synthesized from different routes [13][14][15][16] . Some heterocyclic compound derived from furfural were prepared previously [17] and here we are going to complete this work by using furfural as precursor for other new heterocyclic compounds which might find an applications as drugs ,since Triazoles such as fluconazole, Isavuconazole, Hexaconazole, epoxiconazole, difenoconazole, tebuconazole etc.,) were commercially used as a fungicidal drugs [18]. In this investigation we use furfural molecule as a core compound for heterocyclic synthesis including diazoles ,triazoles so that to increase their activity through introducing furfural moiety toward their synthesis in a way that will make them suitable for this type of studies which will be investigated in our next work .The synthesized compounds were studied by IR and one of them by 1 HNMR and used for elucidating their structures..…”

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“…Mucobromic acid was also used for the synthesis of 2-hydroxy-3-(2-indolyl)-4-bromo furan-5-one by Suzuki reaction13.Many heterocyclic compounds containing furfural moiety have proved to have many pharmaceutical applications [13,14]. In our present study we started synthesizing nitrogen based heterocycles from furfural as precursor for these compounds which are peridines, pyrimidines and azipene these nitrogen containing compounds have proved their activities against nervous system diseases including depression, psychological disorder and schizophrenia [15][16][17] so they are used as a pharmaceutical compounds for many applications [18][19][20]. Benzodiazepines are effective for treating a range of psychological and neurological disorders, due to its effects on the neurons that DOI: 10.32474/ANOAJ.2019.01.000125 trigger stress and anxiety reactions Carbamazepine, or CBZ, is an anticonvulsant medication and a mood-stabilizing agent.…”