Synthesis of Some Heterocyclic Compounds Using Named Reactions

Synthesis of Highly Substituted Furans via Intermolecular Enynone-Aldehyde Cross-Coupling/Cyclization Catalyzed by N-Heterocyclic Carbenes

“…And they are also useful building blocks in organic synthesis (Scheme a) . Tremendous efforts have been devoted to the development of strategies for the synthesis of substituted furans, to increase their structural diversity, that are valuable in medicinal chemistry and drug discovery. , However, access to polysubstituted furans with desirable substitution patterns is often complicated and circuitous. Furthermore, the current synthesis of such furans typically requires the use of metal catalysts, high reaction temperatures, long reaction time, or multiple components.…”

Electrocatalytic [3 + 2] Annulation for the Synthesis of Polysubstituted Furans

“…Consequently, considerable efforts have been devoted to exploring synthetic routes toward the construction of these motifs with diversity and complexity. Among them, classical Paal–Knorr and Feist–Bénary reactions via 1,4-dicarbonyl cyclocondensation represent the most well-known approaches under strong acid or basic conditions. Cyclization of allenyl/alkynyl alcohol or ketone derivatives was proven to be a powerful method for the synthesis of densely functionalized furans. , A plethora of transition-metal-mediated carbenoid annulation strategies have also been elaborately designed to access polysubstituted furans .…”