2014
DOI: 10.1002/ardp.201300344
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Synthesis of Some New 1,2,4‐Triazole Derivatives Starting from 3‐(4‐Chlorophenyl)‐5‐(4‐methoxybenzyl)‐4H‐1,2,4‐triazol with Anti‐Lipase and Anti‐Urease Activities

Abstract: In the present study, starting compound 4 was prepared by deamination of compound 2 in the presence of hypophosphorous acid and sodium nitrite. Treatment of compound 4 with ethyl bromoacetate produced ethyl[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetate (5), which was converted to the hydrazide derivative (6) by treatment with hydrazine hydrate. The reaction of compound 6 with aromatic aldehydes resulted in the formation of arylidene hydrazides (7). Treatment of 6 with CS 2 in the presenc… Show more

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Cited by 60 publications
(37 citation statements)
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“…SH signal was observed only for compounds 6a, b at 2567, 2536 cm À1 and C¼S was observed only for compounds 6c-h between 1297 and 1326 cm H NMR spectra of these compounds, NH peaks were observed as a singlet between 13.52 and 14.02 ppm, and so their thiocarbonyl form was proved. 13 C NMR spectrum of 6a-h showed signals at 147.83-148.74 and 167.48-169.27 ppm due to C¼N and C¼S, respectively [26][27][28] .…”
Section: Chemistrymentioning
confidence: 99%
“…SH signal was observed only for compounds 6a, b at 2567, 2536 cm À1 and C¼S was observed only for compounds 6c-h between 1297 and 1326 cm H NMR spectra of these compounds, NH peaks were observed as a singlet between 13.52 and 14.02 ppm, and so their thiocarbonyl form was proved. 13 C NMR spectrum of 6a-h showed signals at 147.83-148.74 and 167.48-169.27 ppm due to C¼N and C¼S, respectively [26][27][28] .…”
Section: Chemistrymentioning
confidence: 99%
“…The starting compound 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl] acetohydrazide (1) was prepared according to our previous report 33 . Reaction of compound 1 with various isothiocyanate resulted in the formation of 2-{[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetyl}-4alkyl/arylthiosemicarbazides (2a-c) 34 .…”
Section: Chemistrymentioning
confidence: 99%
“…The progress of the reaction was monitored by thin layer chromatography (TLC) on silica gel plates (silica gel 60 F 2.54 0.2 mm thickness). Compound 1 was synthesized by the methods reported earlier 33 .…”
Section: Chemistrymentioning
confidence: 99%
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“…1,2,4-Triazoles are very objective for medicinal and pharmaceutical applications. 1,2,4-triazole derivatives investigated due to their wide range of biological activities such as antifungal, antibacterial [2][3][4][5] , ant tubercular 6 , anticonvulsants 7,8 , antiviral 9 , anti-inflammatory [10][11][12] , antioxidant 5,13,and 14 , urease inhibitors 5,15 , lipase inhibitors 15 , and anticancer agents [16][17][18][19][20] . Also they used as anticorrosion 21 , and acid-based indicator 22 .…”
Section: Introductionmentioning
confidence: 99%