Synthesis of some new azoles of potential antiviral activity

Farghaly, Abdel-Rahman; El‐Kashef, Hussein

doi:10.3998/ark.5550190.0007.b07

Cited by 55 publications

(13 citation statements)

References 10 publications

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“…Traditionally, small molecule compounds are the most commonly used agents during the course of antibacterial therapy [1,2]. Heterocyclic compounds are organic molecules, which include guanidines derived from carbazoles and azoles and have shown good antibacterial effect [3,4]. Metal ions of heterocyclic compounds play a major role in the antibacterial activities [5,6].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Therapeutic Agents Composed of Functional Biological Molecules

Zhou

2020

Journal of Chemistry

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Antibacterial agents are a group of materials that selectively destroy bacteria by interfering with bacterial growth or survival. With the emergence of resistance phenomenon of bacterial pathogens to current antibiotics, new drugs are frequently entering into the market along with the existing drugs, and the alternative compounds with antibacterial functions are being explored. Due to the advantages of their inherent biochemical and biophysical properties including precise targeting ability, biocompatibility, biodegradability, long blood circulation time, and low cytotoxicity, biomolecules such as peptides, carbohydrates, and nucleic acids have huge potential for the antimicrobial application and have been extensively studied in recent years. In this review, antimicrobial therapeutic agents composed of three kinds of functional biological molecules were summarized. In addition, the research progress of antibacterial mechanism, chemical modification, and nanoparticle coupling of those biomolecules were also discussed.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Therapeutic Agents Composed of Functional Biological Molecules

Zhou

2020

Journal of Chemistry

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“…35 These five-membered heterocyclic rings have also proved to have very effective antiviral activity against a wide range of viruses, making them of great value in the antiviral research. [36][37][38][39][40][41] Tang et al 45 have reported the synthesis of a series of benzothiazole derivatives bearing 1,3,4-thiadiazole moiety. The newly synthesized compounds exhibited good antivirus activity against tobacco mosaic virus, with compound 3 being the most effective.…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of thiadiazoles, oxadiazoles, triazoles and thiazoles

Tawfik¹,

Liu²,

Farahat³

2020

Arkivoc

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Drugs containing the heterocyclic five-membered thiadiazoles and isosteres possess a wide range of biological activities, including but not limited to, antiviral, antifungal, antihistamine, anticancer. In this study, we list the agents containing thiadiazoles and isosteres which are reported to have antiviral activity. We believe that this compilation will be a useful resource for researchers working in the field of antiviral agents.

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“…16 respectively. Among the 1, 3, 4-oxadiazoles, pyrazole containing 2, 5-disubstituted-1, 3, 4-oxadiazoles are found to have considerable interest in medicinal chemistry because of their various biological characterized possessed by these compounds like antimicrobial, 17 antioxidant, 18 DNA photocleavage activity, 19 anticancer, 20 anti-inflammatory 21 and antiviral 22 activities. On the other hand, hydrazones are of considerable interest in synthetic chemistry and are broadly considered for studies as reaction intermediates or reactants since they can readily undergo various ring closure reactions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of 2-phenyl-5- (1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol- 4-yl) - 1, 3, 4-oxadiazole Scaffolds for Assessing Their Medicinal Potentials

Chennapragada¹,

Palagummi²

2018

IJPER

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Objective: The present research is aimed at the discovery and development of 1-phenyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole derivatives as a series of novel 1, 3, 4-oxadiazoles (7a-7h) through iodine-catalyzed oxidative cyclization of the hydrazone derivatives (6a-6h) in the presence of potassium carbonate as base and DMSO as solvent in good toexcellent yields. Methods: The structures of all the newly synthesized compounds (6a-6h) and(7a-7h) were well characterized by IR, 1H NMR, 13C NMR and HRMS. Furthermore, allthe synthesized compounds (6a-6h and 7a-7h) were evaluated for their antimicrobial andanti-oxidant activities. Results: The research results revealed that the compound 6d (Z)-2-bromo-N'-((1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl) methylene) benzohydrazide) has antimicrobial potent while the synthesized compounds 6a (

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Synthesis of some new azoles of potential antiviral activity

Abstract: Starting from the pyrazole-4-carboxylic acid hydrazide 3, a variety of new oxadiazoles 7-9, 11, 13, 17, 18, triazoles 20, 22-25, thiadiazole 21 and pyrazole derivatives 26-29 have been synthesized.

Cited by 55 publications

References 10 publications

Antibacterial Therapeutic Agents Composed of Functional Biological Molecules

Antibacterial Therapeutic Agents Composed of Functional Biological Molecules

Antiviral activity of thiadiazoles, oxadiazoles, triazoles and thiazoles

Synthesis and Characterization of 2-phenyl-5- (1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol- 4-yl) - 1, 3, 4-oxadiazole Scaffolds for Assessing Their Medicinal Potentials

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