Synthesis of some new C-nucleosides by used l-arabinose and d-glucose

El-Farargy, Ahmed Fouad; Ghonium, Amira Atef

doi:10.3998/ark.5550190.0009.d30

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…L-arabinose is the critical agent in the synthesis of antiviral drug clevudine (Choung et al, 2012) and telbivudine (Jia et al, 2014;Li et al, 2014), which are potent anti-hepatitis B (HBV) agents. It also has great usage in tumor therapy (Loessner et al, 2007;Jeong et al, 2014;Kaluzhny et al, 2009) and chemistry (Yamauchi & Kinoshita, 2001;EL-Farargy & Ghonium, 2008) and biology fields (Becker & Boles, 2003;Jeon et al, 2010). Although it has been known for a long time, the solubility and metastable zone width of L-arabinose in aqueous solution have not been reported before.…”

Section: Introductionmentioning

confidence: 99%

Solubility and Seeded Metastable Zone width of functional sugar L-arabinose

Hu¹,

Huang²,

Zhang³

et al. 2015

Food Sci. Technol (Campinas)

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L-arabinose is widely used in food, medicine, chemistry, and biology fields; however, solubility and seeded metastable zone width (MSZW) of L-arabinose have not been reported in the literature. In this paper, solubility and MSZW of L-arabinose in aqueous solution were determined. Solubility of L-arabinose was measured in the range of 20-68 °C by a conventional equilibrium solubility method and quantitation was determined using the ion chromatography technique. Seeded MSZW was determined in the range of 51-73% by the calorimetric method. The effect of two salts (potassium chloride and calcium chloride) on the solubility and MSZW of L-arabinose were also evaluated. Results showed that both potassium chloride and calcium chloride increased the solubility of L-arabinose, and this increase was intensified with temperature rise. The MSZW of L-arabinose was not constant but a spread. Potassium chloride increased the MSZW of L-arabinose. However, the effect of calcium chloride on MSZW of L-arabinose was concentration dependent. Conclusion: the L-arabinose solubility increased with the increase in temperature, and both potassium chloride and calcium chloride increased the solubility of L-arabinose in aqueous solution. The seeded MSZW of L-arabinose is not a constant; it increases in the presence of potassium chloride and varies with the change in calcium chloride concentration.

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Section: Introductionmentioning

confidence: 99%

Solubility and Seeded Metastable Zone width of functional sugar L-arabinose

Hu¹,

Huang²,

Zhang³

et al. 2015

Food Sci. Technol (Campinas)

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“…In fact, corncob is an important raw material 2 of 9 for producing pentose [3], hydroxymethylfurfural [4], ethanol [5], xylitolp [6], levulinic acid [7], formic acid and acetic acid [8], etc. These products are highly applicable in various fields including food, medicine [9,10], and fine chemicals [11,12]. However, due to production costs and technical restrictions, large majority of corncobs are still incinerated, giving rise to huge waste of resources and severe environmental problems.…”

Section: Introductionmentioning

confidence: 99%

A New Approach for Economical Pretreatment of Corncobs

Wang

et al. 2019

Applied Sciences

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Huge amounts of waste acid and wastewater are generated during the corncob pretreatment process, which limits chemical utilization of biomass resources to produce value-added chemicals and biofuels. In this work, a new approach, i.e., reuse of the corncob pretreatment liquid, is proposed toward diminishing acid and water consumption. Metal ions and soluble proteins in the pretreatment liquid were analyzed by the inductively coupled plasma atomic emission spectroscopy (ICP-AES) and the Coomassie rilliant blue G250 method, respectively. The results showed that the increament of soluble proteins and total metal ions in solution by three reuse rounds of the pretreatment liquid is nearly identical to that in solution by new added pretreatment liquid. Besides, the surface morphology of the corncob obtained by three reuse rounds of the liquid pretreatment did not exhibit significant difference comparing to that of the corncob acquired by new liquid pretreatment. Further, selection basis of an optimal reuse round of the pretreatment liquid is suggested depending on the effective removal of soluble proteins and metal ions from corncobs. By repeated use of the pretreatment liquid, the consumption of both acid and water during the corncob pretreatment process is expected to be significantly reduced.

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Synthesis and Antimicrobial Activities of New S-Nucleosides of Chromeno[2,3-B]Pyridine Derivatives and C-Nucleosides of [1,2,4]Triazolo[1,5-A]Quinoline Derivatives

Ghoneim¹,

El‐Farargy²,

Abdelaziz³

2014

Nucleosides, Nucleotides and Nucleic Acids

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Direct preparation of 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile 2 and 1,2-diamino-1,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-3-quinolinecarbonitrile 11, which were utilized as starting products for the synthesis of S-nucleoside analogues 10 and 15 and C-nucleoside analogues 12 and 13, is presented in the current study. The antibacterial and antifungal activities of these new compounds were evaluated. The structures of the new products were confirmed on the basis of elemental and spectral analysis results.

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Synthesis of some new C-nucleosides by used l-arabinose and d-glucose

Cited by 4 publications

References 11 publications

Solubility and Seeded Metastable Zone width of functional sugar L-arabinose

Solubility and Seeded Metastable Zone width of functional sugar L-arabinose

A New Approach for Economical Pretreatment of Corncobs

Synthesis and Antimicrobial Activities of New S-Nucleosides of Chromeno[2,3-B]Pyridine Derivatives and C-Nucleosides of [1,2,4]Triazolo[1,5-A]Quinoline Derivatives

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