Synthesis of some new indolo[2,3-c]isoquinolinyl pyrazoles, -1,3,4-oxadiazoles and their biological activities

The synthesis ofN‐containing heterocyclic compounds catalyzed by copper/L‐proline

“…Benzopyridoindolone is one kind of molecular structure that is prevalent in a wide range of biological and medicinal compounds. [ 70 ] In 2017, the method for the construction of pyridoindolone derivatives 201 could be realized by copper‐catalyzed cascade reaction of 2‐iodobenzamides 199 and 2‐iodobenzylcyanides 200 (Scheme 32). [ 71 ] This methodology was wide substrate scope and excellent product yields, but only 2‐iodobenzamides were accommodative in this reaction.…”

Organocatalytic asymmetric synthesis of multifunctionalized α-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells

“…For example, both natural alkaloid grossularine-2 2 ( I ) and synthetic drug leads 3 ( II ) possess remarkable cytotoxicity against tumor cell lines. Synthetic α-carboline compounds III and IV are potential antibacterial and antifungal agents, 4 respectively. On the other hand, C3-modified spiro-oxindoles with a nitrogen-containing hexatomic ring represent privileged frameworks that have been proved to be highly efficient antitumor agents (Fig.…”

Synthesis of novel indolo[3,2-c]isoquinoline derivatives bearing pyrimidine, piperazine rings and their biological evaluation and docking studies against COVID-19 virus main protease

“…An insight into literature survey showed that many hybridized α-, δ-carboline (indolo[2,3-c]isoquinoline, indolo[3,2-c]isoquinoline) analogs demonstrate diverse biological activities like bactericidal, fungicidal [37] , anticancer [38] , antineoplastic [39] , antitumor [40] , antihistaminic [41] , oxytocic [ 42 , 43 ], analgesic and anti-inflammatory activities [44] . In recent years, applications of indolo[3,2-c]isoquinoline include development of antimicrobial, antioxidant, anticancer and anti-TB [45] , [46] , [47] properties from our laboratory. Based on this speculation with a broader outlook in medicine citations, this area was considered.…”