Synthesis of Some New Isatin Derivatives and Identification of Their Structures

Abstract

Indole, which has an important role in heterocyclic ring systems, exhibits significant biological effects. Isatin (1H-indole-2,3-dione) has been used as a reagent in a large number of synthesis due to its biological properties. In addition, it is a heterocyclic ring system used for obtaining and other reactions of indole and quinoline derivatives. In this study, two new Schiff base compounds were synthesized by the reaction of 2-aminoantracene with an isatin/5-nitroisatin. The structure of the synthesized compounds, were elucidated by spectroscopic methods using IR, 1 H-NMR, 13 C-NMR spectra and Mass analysis.

Review of Chemical, Pharmacological, Biological Activities of Isatin and Its Derivatives – Part-2 (2002 To 2020)

“…The synthesis of schiff and mannich of isatins were reported with various substitutents [5][6][7] . Some novel applications of isatin 8 in the synthesis of organic compounds were also reported.…”

Inversion kinetics of some E/Z 3-(benzylidene)-2-oxo-indoline derivatives and their in silico CDK2 docking studies

“…The recognition of the importance of CDKs to the process of cell division has stimulated an interest in them as potential targets for the management of cancer. 9,10 Molecules having the 2-oxo-indoline scaffold usually compete with ATP for binding in the enzyme active site, and prevent phosphate transfer from ATP to the appropriate residue (Tyr, Ser, Thr). Thus, they block auto- and substrate phosphorylation, and therefore signal transduction and oncogenic activity.…”