Synthesis of Some New Isoxazoline Derivatives of Chalconised Indoline 2-one as a Potential Analgesic, Antibacterial and Anthelmimtic Agents

Abstract

A series of novel 1[5”-(2”’-substituted phenyl)-4”,5”’-dihydro isoxazole-3”-yl]-3-[(4 substituted phenyl)imino]1-3-dihydro-2H-indole-2-one were synthesized from different substituted chalconised indole-2,3-dione was prepared from the different chalconised Isatin. The structures of the compounds were elucidated by elemental and spectral (IR, 1H NMR, and MS) analysis. The synthesized compounds were screened for their analgesic activity by the acetic acid induced Writhing method and in vitro antimicrobial activity against the Gram-positive bacteria—Staphylococcus aureus and the Gram-negative bacteria—Pseudomonas auroginosa, Pseudomonas mirabilis, and E. coli by the cup plate agar diffusion method. Compounds 6a1, 6a3, 6b3, and 6b2 were found to be active against bacteria. The compounds 6a1, 6b3, and 6a3 show a significant analgesic activity. Synthesized compounds also screened for anthelmintic activity against Pheretima posthuma. Compounds 6a1, 6b1, and 6b3 show significant anthelmintic activity.

Design, synthesis, and biological evaluation of thiourea and guanidine derivatives of pyrimidine-6-carboxylate

“…Substitution of -OH group (5b) on the phenyl ring increases the acidic character of the phenyl ring, which leads to an easy release of H ? , which is responsible for scavenging action of DPPH and the study of Mondal et al [25] also supports our observation, who explained the role of the -OH group in increasing the antioxidant activity. Compound 7b also showed significant free radical scavenging activity, which may be due to the presence of disubstituted amine on the phenyl ring of pyrimidine moiety.…”

Synthesis, photoluminescence and biological properties of terbium(III) complexes with hydroxyketone and nitrogen containing heterocyclic ligands

“…Further, it is also noticed that substitution of dimethoxy group on phenyl ring increases the activity. The antioxidant activities shown by complexes are favoured by Kumar [30] and Mondal [31]. In general, presence of electron withdrawing group on phenyl ring cause increases in the antioxidant activity.…”

Study of binding interaction between anthelmintic 2, 3-dihydroquinazolin-4-ones with bovine serum albumin by spectroscopic methods

“…All the synthesized derivatives 2(a-i) were tested for anthelmintic activity as per the reported protocols [35]. Pheretima posthuma of length (8 71 cm) were randomly selected for the present study.…”