Synthesis of Some New Mannich Bases of 6-Acyl-5-Chloro-2-Benzoxazolinones : Bazi Yeni̇ Mannich Bazi 6-Açi̇l-5-Kloro-2-Benzoksazolinonlarin Sentezleri̇

Özkanlı, Fügen

doi:10.1501/eczfak_0000000401

Ankara Universitesi Eczacilik Fakultesi Dergisi

2004

DOI: 10.1501/eczfak_0000000401

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Synthesis of Some New Mannich Bases of 6-Acyl-5-Chloro-2-Benzoxazolinones : Bazi Yeni̇ Mannich Bazi 6-Açi̇l-5-Kloro-2-Benzoksazolinonlarin Sentezleri̇

Fügen Özkanlı¹

Abstract: Ankara Üniversitesi Eczacılık Fakültesi Dergisi farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayın ortamıdır. Bu dergi yılda 4 sayı yayınlanır. Yayımlanan yazıların sorumluluğu yazar(lar)ına aittir. Dergiye gönderilen makalelerin daha önce tamamen veya kısmen başka bir yerde yayınlanmamış veya yayını için başka bir yere başvuruda bulunulmamış olması gereklidir. Makaleler derginin arka sayfalarında yer alan yazım kurallarına … Show more

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2024

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Synthesis, Characterization, of Antioxidant Activity Mannich Bases from 2-Benzoxalinones

Başoğlu,

Becer,

Ercetin

et al. 2024

Karadeniz Fen Bilimleri Dergisi

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This study aimed to synthesize a series of 3-substituted piperazinomethyl derivatives (BzO1-4) via a Mannich reaction and evaluate their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and ferrous ion- chelation capacity assays. The synthesis process involved precise techniques, and the compounds were characterized using elemental analysis, FT-IR, and 1H-NMR spectroscopy. Notably, BzO-1, featuring a 4-methylphenyl substituent, emerged as a novel compound within this series, demonstrating the highest antioxidant activity among the four derivatives tested. A considarable performance of BzO-1 was evident in its ability to neutralize free radicals and ferric ion-chelating capacity indicating its potential as a potent antioxidant agent. The detailed characterization data provided insights into the molecular structures and electronic environments of the synthesized compounds, which were crucial for understanding their antioxidant mechanisms. These findings suggest that the structural modifications in these piperazinomethyl derivatives significantly influence their antioxidant properties, and the novel BzO-1 compound holds promise for further development and application in antioxidant therapy.

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Synthesis, Characterization, of Antioxidant Activity Mannich Bases from 2-Benzoxalinones

Başoğlu,

Becer,

Ercetin

et al. 2024

Karadeniz Fen Bilimleri Dergisi

View full text Add to dashboard Cite

show abstract

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Synthesis of Some New Mannich Bases of 6-Acyl-5-Chloro-2-Benzoxazolinones : Bazi Yeni̇ Mannich Bazi 6-Açi̇l-5-Kloro-2-Benzoksazolinonlarin Sentezleri̇

Cited by 1 publication

References 8 publications

Synthesis, Characterization, of Antioxidant Activity Mannich Bases from 2-Benzoxalinones

Synthesis, Characterization, of Antioxidant Activity Mannich Bases from 2-Benzoxalinones

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