Synthesis of some new pyrazolo[3,4-d]pyrimidine derivatives of expected anticancer and radioprotective activity

MOLECULAR DOCKING STUDY ON 1H-(3,4d) PYRAZOLO-PYRIMIDINES AS CYCLIN DEPENDANT KINASE (CDK2) INHIBITORS

“…The scaffold has also shown potent xanthine oxidase inhibitors and adenosine receptor antagonistic activity [20]. The condensed heterocyclic derivatives have also shown radioprotective activities [10]. Extensive studies have shown pyrazolo [3,4-d]pyrimidines to have anticancer potential due to multiple target inhibition of epidermal growth factor (EGFR) inhibitors, mammalian target of rapamycin (mTOR) inhibitors [21], Src or dual Src/Abl inhibitors [22], cyclin-dependent kinase (CDK) inhibitors, glycogen synthase kinase-3b (GSK-3b) inhibitors [23][24][25], xanthine oxidase inhibitors through modulating oxygen stress in cancer cells [26].…”

“…2) with very promising IC50 values [7]. [3,4-d] pyrimidines derivatives have gained considerable attention due to their reported anticancer and antileukemic activities [9][10][11][12][13]14]. The biological effect is attributed to their cyclin-dependent kinase inhibitor [15][16][17] and tyrosine kinase inhibitory activity [18][19].…”

One-pot synthesis and antimicrobial activity of new 4,6-disubstituted-3,4-dihydropyrimidine-2(1H)-thiones

“…Pyrimidine rings, on the other hand, are important substructures in natural products like nucleic acids and vitamin B1 [13,14]. Different pyrimidines have shown a pharmaceutical importance because of their biological activity such as antifungal [15], antiviral [16][17][18], anti-inflammatory [19], antileishmanial [20] and anticancer [20,21].…”

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

“…Pyrazolo [3,4-d]pyrimidines and their related fused heterocycles are of considerable significance chemical and pharmaceutical utility as purine analogs [3] and many of their derivatives were reported to possess antiviral [1,4] antimicrobial [2,5] anti-inflammatory [6,7] anticancer [8] and xanthine oxidase inhibitor [9] activities.…”