Synthesis of Some Novel 5-(8-Substituted-11H-Indolo[3,2-c]Isoquinolin-5-ylthio)-1′,3′,4′-Oxadiazol-2-Amines Bearing Thiazolidinones and Azetidinones as Potential Antimicrobial, Antioxidant, Antituberculosis, and Anticancer Agents

The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

“…The Compounds 42g and 42h also expressed enhanced activity at half maximal inhibitory concentration of 1.54 and 1.82 µM (MCF-7), 1.78 and 1.85 µM (A549), 1.56 and 1.80 µM (HeLa). The other compounds showed moderate effect (42a-42c) or were inactive (Compound 11, Figure 7) [25]. Similar results were obtained also for series of Compound 12 and 43a-43h (Figure 7 and Figure 18).…”

“…The Compounds 11 and 43a (Figures 7 and 18) exhibited strong antimicrobial activity against four bacterial (E. coli, K. pneumoniae, S. aureus and B. subtilis) and three fungal (A. niger, Aspergillus oryzae and C. albicans) strains with MIC = 1.5 µg/mL. This activity was comparable or slightly better than reference drugs streptomycin, ciprofloxacin and fluconazole [25,26].…”

“…The Compounds 11 and 43a (Figure 7 and Figure 18) exhibited strong antimicrobial activity against four bacterial (E. coli, K. pneumoniae, S. aureus and B. subtilis) and three fungal (A. niger, Aspergillus oryzae and C. albicans) strains with MIC = 1.5 µg/mL. This activity was comparable or slightly better than reference drugs streptomycin, ciprofloxacin and fluconazole [25,26]. Among the 3-amino-2-aryl/alkylthiazolidin-one derivatives, Compound 115 (Figure 50) showed higher inhibitory activity (inhibition zone -8-17 mm) than standard chloramphenicol (5-15 mm) to concentration 150 µg/mL against all tested strains (Proteus vulgaris, E. coli, K. pneumoniae, P. aeruginosa and S. aureus) [122].…”

“…The very promise level of antimycobacterial activity against M. tuberculosis H37Rv showed compounds 42c (MIC = 1.5 µg/mL) and 43g as well as 43h (MIC = 0.8 µg/mL) (Figure 18) [25,26]. Worth noticing good antimycobacterial activity of Compounds 113a-113d (Figure 49) that inhibited mycobacterial growth of M. tuberculosis H37Rv strain at MIC = 1.56 µg/mL [120].…”

“…Compound 12 with indolyl-pyridine moiety in structure showed more potent radical scavenging activity than 11 (80.89%, 86.02%, 89.86% and 92.05 7) demonstrated excellent radical scavenging activity (78.83% of inhibition at concentration 100 µg/mL). The evaluation was carried out by the DPPH test [25]. Compound 12 with indolyl-pyridine moiety in structure showed more potent radical scavenging activity than 11 (80.89%, 86.02%, 89.86% and 92.05 % at concentration 25, 50, 75 and 100 µg/mL, respectively) [26].…”