Synthesis of some novel benzimidazole derivatives and it's biological evaluation

One pot synthesis of 1-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d] imidazoles in ionic liquids: Evaluation of antioxidant and antimicrobial activities

“…The benzimidazole has been an important pharmacophore and privileged structure, encompassing a diverse range of their biological properties [1,2]. Benzimidazoles have been reported as antimicrobial [3][4][5][6][7][8][9][10], antiviral [11][12][13][14], antioxidant [15], anti-inflammatory [16,17], antitumor [18] and anticancer agents [19][20][21]. 1,2,3-Triazoles due to their exclusive chemical and structural properties, have acknowledged a lot of awareness over the past decades and found extensive applications in medicinal chemistry [22][23][24][25], biological activities such as anti-HIV [27] and antimicrobial [27,28].…”

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives.

“…Benzimidazole derivatives possess great importance in medicinal chemistry due to wide variety of pharmacogical activity 6,7 in controlling cardiovascular diseases 8 , anticancer properties 9 , antiinflamatory 10 , antibacterial 11 , antifungal 12 , antidiabetic 13 and anti HIV 14 activity and some benzimidazoles are antioxidant [15][16] .The special benzene-fused imidazole ring could readily interact with various active targets in biological system via diverse noncovalent interactions like hydrogen bonds, coordination, ion dipole, cation À-À stacking and hydrophobic effect as well as van der Waals force, therefore benzimidazole-based derivatives exhibit various bioactivities 17 . Benzimidazole and its derivatives are used in organic synthesis and vermicides or fungicides as they inhibit the action of certain microorganisms.…”