Synthesis of Some Novel N-alkylated 2-chloro-Benzimidazole Derivatives and their Biological Evaluation

Abstract

A series of novel N-substituted benzimidazole derivatives have been synthesized by the condensation of ortho-phenylenediamine and urea, subsequent reaction of the product obtained with Phosphoryl chloride to give 2-Chloro-1H-benzimidazole. Using this compound alkylation done at the benzimidazole-NH position with different benzyl halide reagent leading to the functionalized derivatives. Newly synthesized derivatives (6a to 6h) have been elucidated on the basis of spectral and analytical data like melting point, IR, 1 H-NMR, Mass spectroscopy and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity. This displayed some promising results towards testing organism in-vitro.