Synthesis of Some Novel N⁷-tetrazolo[5,1-f]-1,2,4-triazin-8-(7H)-one Compounds as Potential Antimicrobial Agents

Abstract

A series of new N 7-tetrazolo[5,1-f ]-1,2,4-triazin-8-(7H)-one derivatives 4−16 were designed and synthesized from 3 with different reagents. The newly prepared compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains.

Synthesis, Structure, and Biological Screening of Some Condensed Heterocyclic Compounds from 8-Chlorotetrazolo [5,1- f]-1,2,4-Triazine Precursor

“…The 1 H NMR spectrum of compound 3b displayed a CH proton as a quartet signal at 4.42 ppm and CH 3 protons as a doublet signal at 1.51 ppm. The 1 H NMR spectrum of compound 4 showed a triplet signal at 3.62 ppm assigned for CH 2 CO and triplet signal at 3.22 ppm assigned for NCH 2 beside exchangeable OH and NH protons. The mass spectra of 3a,b and 4 revealed the correct molecular ions which were supported by elemental analysis.…”

“…11,12 They have emerged as antibacterial, [2][3][4][5][6][7][8]13 antiproliferation, 14 anticancer, 14 and anticonvulsant 15 agents. In this article, it is our intention to enlarge the area of the investigation towards tetrazolo-heterocycles using framework different reagants and expected interesting antimicrobial agents.…”