Synthesis of some novel pyrazolopyrimidotriazepine, pyrazolotriazolopyrimidine, and pyrazolopyrimidotetrazine derivatives

Abstract

Reaction of ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate with thiocarbohydrazide yielded 5-amino-6-hydrazinyl-1-phenyl-1H-pyrazolo [3,4-d] pyrimidine-4-(5H)one (1), which used as precursor to synthesize pyrazolopyrimidotriazepine 2, pyrazolopyrimidotriazines 5-7, pyrazolotriazolopyrimidines 8-14, pyrazolopyrimidotetrazines 17. The structures of the newly synthesized compounds were confirmed by spectral data (IR, NMR, elemental analysis, and mass spectra).