“…4 Therefore, several improved reaction protocols for the synthesis of Biginelli compounds have been reported, either by modification of the classical one-pot Biginelli reaction, novel multi-step methods, use of combinatorial approaches or microwave irradiation techniques. 5 In further years, improvement in Biginelli compounds is done by using different catalysts such as polyphosphate ester (PPE) 6 , Bronsted acids viz. p-toluenesulfonic acid 7 , potassium hydrogen sulphate 8 , chloroacetic acid 9 , titanium (IV) chloride 10 , ruthenium (III) chloride 11 , scandium (III)triflate 12 , Iodine-alumina 13 ,Cobalt(II)acetate 14 ,sulphated zirconia 15 , ferric chloride hexahydrate 16 , MgBr 2 17 , nbcl 5 18 , Lewis acids 19,20 viz.…”