Synthesis of Some Novel Substituted Purine Derivatives as Potential Anticancer, anti‐HIV‐1 and Antimicrobial Agents.

Abstract

Some of the products show antitumor activity [e.g. (VIIa), (VIIb), (IIIa)]. Compound (IXb) possesses moderate in vitro anti-HIV activity and various derivatives exhibit promising antimicrobial effects. -(RIDA, S. M.; ASHOUR, F. A.; EL-HAWASH*, S. A. M.; EL-SEMARY, M. M.; BADR, M. H.; Arch.

Synthesis of 9-Substituted Derivatives of tert-Butyl 6-(9h-Purin-6-Ylthio) Hexylcarbamate

“…In conclusion, we have synthesized 9-substituted derivatives of tert-butyl 6-(9H-purin-6-ylthio) hexylcarbamate in good yields and characterized by 1 H NMR, IR and LCMS spectral data.…”

“…The purine ring system possesses undisputed biological importance and it is considered to be one of the most important heterocyclic rings in nature [1]. Cells obtain purine nucleotides through two separate metabolic pathways, de novo purine synthesis and salvage of extracellular purine bases and nucleotides [2].…”

“…Therefore, de novo purine synthesis and several enzymes involved in the purine metabolism pathway are important targets for antimetabolites [2]. Purine antimetabolites have been used in the development of many potent medicinal agents, which exhibited antineoplastic, antileukemic, antiviral, antibacterial, and antifungal activities [1][2][3][4]. The purine nucleoside analogs are also used in the treatment of autoimmune diseases [5].…”

Synthesis, anticancer, anti-HIV-1, and antimicrobial activity of some tricyclic triazino and triazolo[4,3-e]purine derivatives

“…This study is a continuation to previous efforts (Rida et al, 2005(Rida et al, , 2007 aiming to locate novel synthetic lead compounds for future development as anticancer, antiviral and/or antimicrobial agents. In our earlier study (Rida et al, 2007), we reported the synthesis and evaluation of in vitro anticancer, anti-HIV-1 and antimicrobial activities of a number of new 8-substituted methylxanthines.…”

“…In our earlier study (Rida et al, 2007), we reported the synthesis and evaluation of in vitro anticancer, anti-HIV-1 and antimicrobial activities of a number of new 8-substituted methylxanthines. The compounds were designed to comprise the purine nucleus linked at C-8 with various heterocyclic ring systems either directly or through a two-nitrogen atom spacer.…”