Synthesis of Some Novel Substituted Phenyl β, β-Diphenyl Propanoate with Analgesic and Anti-inflammatory Activity

Dhall, Harshita; Kumar, Anil; Mishra, Arun Kumar

doi:10.2174/1573407213666161205161135

Cited by 10 publications

(2 citation statements)

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“…The first step involves the synthesis of diastereomeric 3-hydroxy-2-methyl-3-(4-biphenylyl) butanoic acids whereas the second step was a modified Reformatsky reaction in presence of Zn in tetra-hydrofuran (THF) at -5 to 10 ºC between the synthesized compound of the first step and 4-acetyl phenyl. The synthesized compounds were screened for anti-inflammatory activity, and only two compounds (1,2) showed the strongest anti-inflammatory activity 47,48 . Gupta R. et al, synthesized 2-(4-secbutyl-phenyl)propionic acid-pyrrolidin-2-ylcarbamoyl methyl esters by refluxing ibuprofen with 2-aminopyridine in chloroacetyl chloride in presence of glacial acetic acid.…”

Section: Anti-convulsant Activitymentioning

confidence: 99%

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2020

IJPSR

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Arylpropionic acid derivatives are an important class of NSAIDs. Ibuprofen, 2-(4-isobutylphenyl) propionic acid, is known as NSAIDs. Arylpropionic acid derivatives have a broad biological activity, including antibacterial, anticonvulsant and anticancer activity, analgesic, and anti-inflammatory. In addition to the most powerful ingredients used in analgesic and antipyretic fields, such as ibuprofen, Oxaprozin, Ketoprofen, and Phenoprofen, aryl propionic acid derivatives play an important role in treating other symptoms. The possible improvements in the activity can be further achieved by slight modifications in the substituent on the basic aryl propionic acid. According to Grigoryan et al., 2019 studies reveal that the replacement of the carboxyl group by tetrazole ring, hydroxamate, ester, alcohol, and amide groups forms compound showing lower activity (antiinflammatory, anti-nociceptive, ulcerogenic activity). The presence of a carboxyl group in the parent molecule of aryl propionic acid is important for broad-spectrum pharmacological activity. This review focused on recent advances and recent research on aryl propionic acid derivatives compared to medicinal chemistry. INTRODUCTION: Medical chemistry is an area that determines the effect of chemical composition on biological activity. Medical chemistry has been expanded with the help of experimental methods for predicting the composition of new compounds that rely heavily on structural changes and the determination of biological properties.

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Section: Anti-convulsant Activitymentioning

confidence: 99%

“…The synthesized compounds in Table 2 were further screened for in-vitro anticancer activity. Compounds (1-7) showed potent anticancer activity when the comparison was made with Cisplatin [26][27][28][29][30] .…”

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confidence: 99%

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2020

IJPSR

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The Novel Trends in Asymmetric Catalysis

Verma,

Singh,

Prasad

2024

Sustainable Green Catalytic Processes

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Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Umpolung 1,4‐Addition of Aryl Iodides to Enals

Yang

Ling

et al. 2019

Angewandte Chemie

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An umpolung 1,4‐addition of aryl iodides to enals promoted by cooperative (terpy)Pd/NHC catalysis was developed that generates various bioactive β,β‐diaryl propanoate derivatives. This system is not only the first reported palladium‐catalyzed arylation of NHC‐bound homoenolates but also expands the scope of NHC‐induced umpolung transformations. A diverse array of functional groups such as esters, nitriles, alcohols, and heterocycles are tolerated under the mild conditions. This method also circumvents the use of moisture‐sensitive organometallic reagents.

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Synthesis of Some Novel Substituted Phenyl β, β-Diphenyl Propanoate with Analgesic and Anti-inflammatory Activity

Cited by 10 publications

References 0 publications

Untitled

Untitled

The Novel Trends in Asymmetric Catalysis

Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Umpolung 1,4‐Addition of Aryl Iodides to Enals

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