Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents

Synthesis of some new amide-linked bipyrazoles and their evaluation as anti-inflammatory and analgesic agents

“…In the course of a research program aiming at finding out new lead structures that would act as potent anti-inflammatory agents, we have reported the synthesis and anti-inflammatory activities of some lead compounds comprising mainly the pyrazole counterpart substituted with various functionalities and attached to different heterocyclic ring systems through various linkages [27][28][29][30][31] . In particular, potential anti-inflammatory activity was displayed by the pyrazolyl derivatives (A-C; Figure 1) 28,30 and the bipyrazolyl lead structure (D; Figure 1) 27 .…”

Synthesis, Characterization and Antimicrobial Evaluation of Substituted 1,2,4-Triazole Thiones Containing Pyrazole Moiety

“…These days, the fusion of medicinally important heterocyclic rings to prospective pharmaceutical candidates is a major strategy to achieve greater activity and wider medicinal spectrum. Keeping this in view, the authors herewith report the synthesis and pharmacological evaluation of 1,2,4-triazole thiones fused with pyrazole, an another medicinally important heterocyclic ring system having broad pharmacological spectrum [17][18][19][20][21][22][23]. A number of compounds containing diverse pharmacological importance is reported from these laboratories [24,25] Material and Method All Chemicals and regents were procured from Ranbaxy Laboratories Ltd, Chemical Division, India.…”

Synthesis, Biological Evaluation of Some 2,3-dihydropyrazoles and Thiazoles as Anti-inflammatory and Antibacterial Agents

“…Besides this, there are several reports in the literature on the antiinflammatory [17][18][19][20] and antimicrobial properties [21][22][23] of pyrazoles. However studies investigating the potential of pyrazole derivatives as dual antimicrobial-anti-inflammatory agents have only recently been initiated [24][25][26][27]. Thiazoles and their derivatives are also known to exhibit antimicrobial [28,29] as well as anti-inflammatory activity [30-chalcone analogues as anticancer agents with a brief summary about therapeutic potential of chalcones, mechanism of anticancer action of various chalcone analogues, and current and future prospects related to the chalcones-derived anticancer research.…”

“…Accordingly pyrazoles (4) [27,40,41] were treated with thiosemicarbazide in the presence of catalytic amount of acetic acid to afford the corresponding carbothioamides 6 which on subsequent reaction with various α-haloketones 7a-d afforded the target thiazolylpyrazoles 8a-b. In some of the compounds, this C5-proton of thiazole is merged with other aromatic protons.…”