Synthesis of some pyridylamino‐1,4‐disubstituted phthalazines

Abstract

Two general procedures involving the condensation of phthalonitrile or 1,3‐diiminoisoindoline with various aminopicolines, followed by ring expansion with hydrazine to the corresponding phthalazine are described. Syntheses are reported of 1, 4‐di(3′‐methyl‐2′‐pyridyl) aminophthalazine, 1,4‐di(5′‐methyl‐2′‐pyridyl)aminophthalazine, and 1,4‐di(4′, 6′‐dimethyl‐2′‐pyridyl)aminophthalazine.

Copper coordination chemistry of novel octadentate, tetranucleating, bis(diazine) ligands. Structural and magnetic properties of tetranuclear complexes involving a rectangular array of copper(II) centers

“…Clearly the tautomeric mixture involves NH protons at both ring and exocyclic sites, a feature observed for the related ligand l,4-bis(2'pyridylaminojphthalazine and its alkylated derivatives. 13 In these compounds, NH resonances were observed at 8.7-8. "B^i s the mean of the principal axes of the thermal ellipsoid.…”