Synthesis of some quinazolinones inspired from the natural alkaloid L<i>-</i>norephedrine as EGFR inhibitors and radiosensitizers

Ghorab, Mostafa M.; Abdel‐Kader, Maged S.; Alqahtani, Ali S.; Soliman, Aiten M.

doi:10.1080/14756366.2020.1854243

Cited by 17 publications

(5 citation statements)

References 43 publications

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“…The quinazoline system comprises three distinct members: 2-quinazolinone, which possesses a carbonyl group at the C-2 position (1); 4-quinazolinone, which features a carbonyl group at the C-4 position (2); and 2,4-quinazolinedione, which contains two carbonyl groups at both the C-2 and C-4 positions (3) [25,26]. Due to their wide range of pharmacological properties, which include anti-cancer, anti-viral, anti-bacterial, anti-tubercular, analgesic, anti-hypertensive, anti-inflammatory, anti-diabetic, sedative-hypnotic, anti-histaminic, anti-convulsant [22,23,[27][28][29]. With high therapeutic activity against solid tumors, quinazoline and its derivatives have been discovered to be a family of cancer chemotherapeutic drugs (Figure 1).…”

Section: Quinazoline As Anticancer Agentsmentioning

confidence: 99%

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article

Mansour,

Abbas,

AboulMagd

et al. 2023

Journal of advanced Biomedical and Pharmaceutical Sciences

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In recent years, the use of quinazoline and its derivatives as structural scaffolds has shown significant promise in drug design. These compounds have shown significant biological efficacy in the treatment of a variety of diseases, including cancer. Quinazoline has shown a significant reduction in adverse effects and improved treatment effectiveness, making it a very attractive candidate for further investigation and advancement in therapeutic interventions. This review provides a focus on the use of small-molecule targeted therapy. The discussion briefly introduces the epidermal growth factor receptor tyrosine kinase (EGFR TK), its mutations, and the development of innovative molecules in this domain. Furthermore, the current review digs into the concept of multi-targeted anticancer agents, particularly on quinazoline-based compounds that can obstruct several targets. Notably, these targets include EGFR/VEGFR dual inhibitors, EGFR/HDAC dual inhibitors, and a variety of other EGFR-related targets.

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Section: Quinazoline As Anticancer Agentsmentioning

confidence: 99%

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article

Mansour,

Abbas,

AboulMagd

et al. 2023

Journal of advanced Biomedical and Pharmaceutical Sciences

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“…A new set of quinazolinone analogs were synthesized by using L-norephedrinewas as a basic unit by Ghorab et al [46]. The cytotoxicity of synthesized compounds was evaluated against the MDA-MB-231, MCF-7, HepG-2, HCT-116 cancer cell lines along with the EGFR activity.…”

Section: Type-i Receptor Tyrosine Kinase Inhibitorsmentioning

confidence: 99%

Recent Advances on Quinazoline Derivatives: A Potential Bioactive Scaffold in Medicinal Chemistry

et al. 2021

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This paper intended to explore and discover recent therapeutic agents in the area of medicinal chemistry for the treatment of various diseases. Heterocyclic compounds represent an important group of biologically active compounds. In the last few years, heterocyclic compounds having quinazoline moiety have drawn immense attention owing to their significant biological activities. A diverse range of molecules having quinazoline moiety are reported to show a broad range of medicinal activities like antifungal, antiviral, antidiabetic, anticancer, anti-inflammatory, antibacterial, antioxidant and other activities. This study accelerates the designing process to generate a greater number of biologically active candidates.

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“…Diazine heterocycles are central components of several drug candidates [4,5]. The benzo-diazene systems of quinoxalines, cinnolines, quinazolines, phthalazines, naphthalenes, and quinolines are used in the preparation of various drugs [6,7]. They are also used in several research studies for the discovery of new drugs [8,9].…”

Section: Introductionmentioning

confidence: 99%

Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines

Zayed

2023

Chemistry

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Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has earned considerable attention due to its importance in the field of medicinal chemistry. The system is of extensive importance due to its comprehensive array of biological activities. Quinoxaline derivatives have been used as anticancer, anticonvulsant, anti-inflammatory, antidiabetic, antioxidant, antibacterial, anti-TB, antimalarial, antiviral, anti-HIV, and many other uses. Variously substituted quinoxalines are significant therapeutic agents in the pharmaceutical industry. This review spotlights on the chemistry, physiochemical characters, synthesis, pharmaceutical products, and medicinal chemistry of various anticancer quinoxaline derivatives that were developed in the last period. It covers the period from 2016 to 2023.

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Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers

Cited by 17 publications

References 43 publications

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article

Recent Advances on Quinazoline Derivatives: A Potential Bioactive Scaffold in Medicinal Chemistry

Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines

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