Synthesis of Some Quinoline Thiosemicarbazone Derivatives of Potential Antimicrobial Activity

Abdel-Moty, Samia G.; Abdelrahman, Mostafa H.; Elsherief, Hosney A.

doi:10.21608/bfsa.2005.65235

Cited by 10 publications

(2 citation statements)

References 12 publications

(11 reference statements)

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“…FTIR spectrophotometer from Shimadzu (model 8101) In KBr pellets, Fourier transform infrared (FT-IR) spectra between 400 and 4000 cm −1 were recorded. A Bruker 400 MHz spectrometer was used to record the 1 H and 13 C NMR spectra in DMSO-d 6 , with tetra methyl silane (TMS) serving as an internal standard. The electron ionization method was utilized to record mass spectra at 70 eV on an HP MS-5988 GS-MS. UV-visible spectra were recorded using a Shimadzu UV mini-1240 spectrophotometer.…”

Section: Characterizationmentioning

confidence: 99%

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Enhanced In Vivo Wound Healing Efficacy of a Novel Hydrogel Loaded with Copper (II) Schiff Base Quinoline Complex (CuSQ) Solid Lipid Nanoparticles

et al. 2022

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Wound dressings created using nanotechnology are known as suitable substrates to speed up the healing of both acute and chronic wounds. Therapeutic substances can be delivered using these materials. In this study, a hydrogel loaded with Cu (II) Schiff base 8-hydroxy quinoline complex (CuSQ) solid lipid nanoparticles (SLN) was formulated to investigate its wound healing potential in an excision wound healing model in rats. The CuSQ SLN were spherical shaped with sizes ranging from 111 to 202 nm and a polydispersity index (PDI) ranging from 0.43 to 0.76, encapsulation efficiency (EE) % between 85 and 88, and zeta potential (ZP) of −11.8 to −40 mV. The formulated hydrogel showed good homogeneity, good stability, and a pH of 6.4 which indicates no skin irritation and had no cytotoxicity on the human skin fibroblast (HSF) cell line. In the in vivo study, animals were placed in five groups: control, standard, plain hydrogel, low dose, and high dose of CuSQ hydrogel. Both doses of CuSQ showed significantly faster healing rates compared to standard and control rats. In addition, the histopathology study showed more collagen, improved angiogenesis, and intact re-epithelization with less inflammation. A significant increase in transforming growth factor-beta1 (TGF-β1) level and increased immune expression of vascular endothelial growth factor (VEGF) by CuSQ treatment validates its role in collagen synthesis, proliferation of fibroblasts and enhancement of angiogenesis. Matrix metalloproteinase-9 (MMP-9) was found to be significantly reduced after CuSQ treatment. Immunohistochemistry of tumor necrosis factor alpha (TNF-α) revealed a marked decrease in inflammation. Thus, we concluded that CuSQ would be a beneficial drug for cutaneous wound healing since it effectively accelerated wound healing through regulation of various cytokines and growth factors.

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Section: Characterizationmentioning

confidence: 99%

“…Due to the presence of oxygen and nitrogen atoms, the 8-hydroxy quinoline (Q) molecule has a strong chelating effect on metal ions. The Q compounds have a variety of pharmacologically advantageous effects, including antibacterial [13], antioxidant, anticancer, and anti-inflammatory effects [14].…”

Section: Introductionmentioning

confidence: 99%