Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity

Turan-Zitouni, Gülhan; Sivaci, Meltem; Kılıç, Fatma Sultan; Erol, Kevser

doi:10.1016/s0223-5234(01)01252-1

Cited by 169 publications

(77 citation statements)

References 6 publications

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“…1,2,4-triazoles and their derivatives are found to be associated with various biological activities such as anticonvulsant [1][2], antifungal [3][4][5], anticancer [6][7][8][9], antiinflammatory [10][11][12] and antibacterial properties [13][14][15][16]. Several compounds ( Figure 1) containing 1,2,4-triazole rings are well known as drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of New Bis-1,2,4-Triazole Derivatives

Bekircan

Bektaş

2006

Molecules

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A series of new 1,2/1,3-bis[o-(N-methylidenamino-3-aryl-5-phenyl-4H-1,2,4-triazole-4-yl)phenoxy]ethane/propane derivatives 4 were prepared in good yields by treatment of 4-amino-3-aryl-5-phenyl-4H-1,2,4-triazoles 2 with certain bis-aldehydes 1. Compounds 4 were reduced with NaBH 4 to afford the corresponding 1,2/1,3-bis[o-(Nmethylamino-3-aryl-5-phenyl-4H-1,2,4-triazole-4-yl)phenoxy]ethane/propane derivatives 5. All new compounds were characterized by IR, 1 H-NMR, 13 C-NMR and mass spectral data.

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Section: Introductionmentioning

confidence: 99%

Synthesis of New Bis-1,2,4-Triazole Derivatives

Bekircan

Bektaş

2006

Molecules

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“…[16][17][18][19] The therapeutic effects of compounds containing 1,2,4-triazole and 1,3,4-oxadiazole rings have been well studied for a number of pathological conditions. 1,2,4-triazoles and their derivatives are found to be associated with various biological activities such as anticonvulsant, [20,21] antifungal, [22][23][24] anticancer, [25][26][27][28] anti-inflammatory [29][30][31] and antibacterial properties. [32][33][34] Also, a series of 1,2,4-triazole derivatives have been patented and extensively employed in agriculture.…”

Section: Introductionmentioning

confidence: 99%

Computational Study of some Double Headed Acyclo-C-Nucleosides

Amara

Tchouar

Belaidi

2015

ILCPA

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ABSTRACT. In the present paper we have a focus in a study of theoretical characterization of three double headed acyclo-C-nucleosides, which are a recent target of experimental studies. The structural and electronic properties of double headed acyclo-C-nucleosides, 1,4-bis(3-mercapto-1H-1,2,4-triazol-5-yl)butane-1,2,3,4-tetrol, 1,4-bis(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)butane-1,2,3,4-tetrol and 5,5'-(1,2,3,4-tetrahydroxybutane-1,4-diyl)bis(1,3,4-oxadiazole-2(3H)-thione), have been investigated theoretically by performing semi-empirical molecular orbital, ab initio Hartree-Fock (HF) and Density Functional Theory (DFT) calculations. Geometries of the three molecules are optimized at the level of Austin Model 1 (AM1). The electronic properties and relative energies of the molecules have been calculated by HF and DFT in the ground state.

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“…The antibacterial properties of the metal complexes and their potential for pharmacological application have been well reported [4][5][6]9,11,15]. The nickel-tetraaza complex has also been found to catalyse the division of DNA molecules [1].…”

Section: Introductionmentioning

confidence: 99%

Complexation of 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-diene dithiocyanate with nickel (II) acetate

Ishak

Yamin²

2013

AIP Conference Proceedings

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Abstract. The complexation of nickel acetate with tetraaza involves deprotonation of protonated amine nitrogen to form neutral ligand coordinated to the nickel via the four nitrogen atom. The dication complex is paired with thiocyanate anions. The complex was characterized by elemental analysis, UV-VIS and FTIR spectroscopic method. The crystal structure of nickel complex characterized by X-Ray crystallography and adopts square planar geometry.

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Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity

Cited by 169 publications

References 6 publications

Synthesis of New Bis-1,2,4-Triazole Derivatives

Synthesis of New Bis-1,2,4-Triazole Derivatives

Computational Study of some Double Headed Acyclo-C-Nucleosides

Complexation of 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-diene dithiocyanate with nickel (II) acetate

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