Synthesis of southern (C1′–C11′) fragment of pamamycin-635A

Synthesis of the L‐Acid (C1–C18) Fragment of Pamamycin‐593 and De‐N‐methylpamamycin‐579

“…Hydride reduction of ketone 13 afforded 17 (27 %) and 8‐ epi ‐ 17 (59 %). The stereochemistry was assigned by comparison with previously reported data 6,7b,9,11. All other hydride reagents tested gave mainly α‐hydroxy compounds 11.…”

Synthetic studies of biologically active natural products contributing to pesticide development

“…16) In a similar manner, the L-acid and S-acid fragments of pamamycin congeners, aerial hyphal differentiation inducers of Streptomyces alboniger, were synthesized. [17][18][19][20] The proposed structures of spirofungin A and B produced by Streptomyces spp., were revised after synthesis of spiroacetal core fragments as C-15 epimers, 21,22) and the formal total synthesis was also achieved (Fig. 2).…”