Synthesis of spirooxindoles with three component reaction between β-ketoesters, malononitrile and isatin derivatives in the presence of Alum.SiO2 nanoparticles as a new nano catalyst

Rohi, Marziyeh; Sadeghi, Bahareh; Moslemin, Mohamadhosaine

doi:10.5902/2179460x20834

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Meanwhile, conventional heating was also tried but yields were poor (0-35% in 46-50 h). The nanocatalyst alum-silica was used to prepare spirooxindole derivatives via βketoesters, malononitrile, and isatins in ethanol solvent under reflux conditions (Figure 35) [84]. Recently, an attractive approach was undertaken by Sadeghi et al, who developed nano-sulfonic acid-derivatised coconut shell powder to catalyse the just-mentioned reaction to obtain products (12 examples, 87-95%) in ethanol solvent after refluxing for only 15 min [85].…”

Section: Spiro Compoundsmentioning

confidence: 99%

Section: Mannich-type Reactionsmentioning

confidence: 99%

“…The classic Mannich reaction involves a C-C bond formation after the reaction of an aldehyde and an amine (to form an imine) with a resonance-stabilised carbon nucleophile The nanocatalyst alum-silica was used to prepare spirooxindole derivatives via βketoesters, malononitrile, and isatins in ethanol solvent under reflux conditions (Figure 35) [84]. The nanocatalyst alum-silica was used to prepare spirooxindole derivatives via βketoesters, malononitrile, and isatins in ethanol solvent under reflux conditions (Figure 35) [84]. Recently, an attractive approach was undertaken by Sadeghi et al, who developed nano-sulfonic acid-derivatised coconut shell powder to catalyse the just-mentioned reaction to obtain products (12 examples, 87-95%) in ethanol solvent after refluxing for only 15 min [85].…”

Section: Mannich-type Reactionsmentioning

confidence: 99%

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Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Bosica

Abdilla

2022

Catalysts

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Multicomponent reactions (MCRs) have been gaining significance and attention over the past decade because of their ability to furnish complex products by using readily available and simple starting materials while simultaneously eliminating the need to separate and purify any intermediates. More so, most of these products have been found to exhibit diverse biological activities. Another paradigm shift which has occurred contemporarily is the switch to heterogeneous catalysis, which results in additional benefits such as the reduction of waste and an increase in the safety of the process. More importantly, it allows the user to recover and reuse the catalyst for multiple runs. In summary, both methodologies adhere to the principles of green chemistry, a philosophy which needs to become overarchingly enshrined. The plethora of reactions and catalysts which have been developed gives hope that chemists are slowly changing their ideology. As a result, this review attempts to discuss multicomponent reactions catalysed by operationally heterogeneous catalysts in the past 10 years. In this review, a further distinction is made between the MCRs which lead to the formation of heterocycles and those which do not.

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Section: Spiro Compoundsmentioning

confidence: 99%

Section: Mannich-type Reactionsmentioning

confidence: 99%

Section: Mannich-type Reactionsmentioning

confidence: 99%

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Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Bosica

Abdilla

2022

Catalysts

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Mechanochemical‐ (Hand‐Grinding‐) Assisted Domino Synthesis of Fused Pyran‐Spirooxindoles under Solvent‐ and Catalyst‐Free Condition

2018

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An efficient and green strategy is developed to synthesize 2‐amino‐2‐oxospiro [indoline‐3, 4′‐pyran]‐3′‐carbonitriles. The method encompasses a domino multicomponent reaction using isatin or acetanaphthelenequinone, malononitrile or ethylcyanoacetate and enolizable 1, 3‐dicarbonyl compounds without any promoter and catalyst in one pot through hand grinding in excellent yields within minutes.

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Recent investigations in the synthesis of spirooxindole derivatives by Iranian researchers

et al. 2020

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Synthesis of spirooxindoles with three component reaction between β-ketoesters, malononitrile and isatin derivatives in the presence of Alum.SiO2 nanoparticles as a new nano catalyst

Abstract: In this reseaech, some of the spirooxindole derivaties were prepared via β-ketoesters, malonoitrile and isatin derivatives in the presence

Cited by 3 publications

References 5 publications

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Mechanochemical‐ (Hand‐Grinding‐) Assisted Domino Synthesis of Fused Pyran‐Spirooxindoles under Solvent‐ and Catalyst‐Free Condition

Recent investigations in the synthesis of spirooxindole derivatives by Iranian researchers

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