Synthesis of stabilized hydroxyapatite nanosuspensions for enamel caries remineralization

Shahmoradi, Mahdi; Rohanizadeh, Ramin; Sonvico, Fabio; Ghadiri, Maliheh; Swain, Michael V.

doi:10.1111/adj.12624

Cited by 11 publications

(9 citation statements)

References 32 publications

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“…In remineralization studies in which HA was used alone, it was found to have positive results on the enamel. 21 Also, studies of children who chew Xylitol gum have found it successful in preventing caries. 22 Our results suggest that the co-use of HA, fluoride, and xylitol use may be beneficial in initial enamel lesions, although further studies of this issue are needed.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of The Effects of Different Remineralization agents on Initial Enamel Lesions by Scanning Electron Microscope and Energy-Distributed X-ray Analysis

Kiliç

Gürbüz

2021

Preprint

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Aim: The present study compares the effectiveness of four different remineralization agents on the demineralized enamel of permanent human incisors. The purpose of this study is to evaluate the effectiveness of remineralization agents on the initial enamel lesion. Material- Methods: Crowns affected by demineralization were divided into two equal parts. The right halves of the teeth were subjected to no other processes after demineralization for control purposes and were kept in artificial saliva for the duration of the experiment. The left halves of the crowns were remineralized using a 5% NaF-containing fluoride varnish (GC MI Varnish GC Corp, Tokyo, Japan), a casein phosphopeptide and amorphous calcium toothpaste (GC Tooth Mousse, GC Corp, Tokyo, Japan), fluoride, hydroxyapatite, and xylitol, containing a water-soluble remineralization paste (Remin Pro™, Voco, Germany) and calcium, magnesium and phosphate-containing gel (Medical Remineralizing gel (R.O.C.S. Trading GmbH, Munich, Germany). After a 21-day remineralization process, and SEM/EDX analysis was performed, and a One Way Anova was used for statistical analysis. Results: According to EDX analysis, the R.O.C.S. medical remineralizing gel was found to have a lower Ca/P ratio than the other material groups (p =0.04). Remin Pro™, Voco, and the R.O.C.S. were higher than the control group in evaluating the Ca / P ratio (p=0.014), (p=0.025). Conclusions: The R.O.C.S group, treated with fluoride-free xylitol-containing, a remineralization agent, showed the lowest Ca/P ratio. Compared to demineralized halves of the teeth (control groups), Remin Pro™, Voco, and R.O.C.S. medical remineralizing gel may be considered as affecting on initial enamel lesions. Key Words: Remineralizing Agents, EDX, SEM, Enamel,

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Section: Discussionmentioning

confidence: 99%

Evaluation of The Effects of Different Remineralization agents on Initial Enamel Lesions by Scanning Electron Microscope and Energy-Distributed X-ray Analysis

Kiliç

Gürbüz

2021

Preprint

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“…To create initial enamel lesions, a demineralisation solution (pH 4.5) was prepared by the Atatürk University Faculty of Pharmacy. The demineralisation solution was prepared as 0.075 mol/L acetic acid, 0.002 mol/L Ca (from CaCl 2 ) and 0.002 mol/L P (from potassium phosphate) 23 . The demineralisation solution was renewed daily.…”

Section: Methodsmentioning

confidence: 99%

“…Ca (from CaCl 2 ) and 0.002 mol/L P (from potassium phosphate). 23 The demineralisation solution was renewed daily. The prepared samples were kept in the demineralisation solution for 8 h/d until 13-20 values had been obtained using DIAGNOdent, then stored in a dark environment in artificial saliva (prepared by the Atatürk University Faculty of Pharmacy) until the experimental materials were applied.…”

Section: What's Newmentioning

confidence: 99%

Evaluation of the effects of different remineralisation agents on initial enamel lesions by scanning electron microscope and energy‐distributed X‐ray analysis

Kiliç

Gürbüz

2021

Int J Clin Pract

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The progression of initial enamel lesions can largely be prevented by early diagnosis and treatment, which aim to protect tooth enamel and dentin. 1 The hard tissues of the teeth are affected by changes in acidity within the oral environment. When the pH falls below 5.5, calcium (Ca) and phosphate (P) ions in the enamel structure migrate away from the tooth tissue, leading to a destructive process known as demineralisation. Without efforts to control the acidification of the oral environment, tooth destruction continues, causing the enamel tissue to soften and become porous. 2 Gradually, caries begin to appear on the tooth surface. Initial enamel lesions occur in the earliest stage of decay; at this stage, caries formation is restricted to the enamel and progression thereof can be prevented with appropriate treatments. 3,4 However, when demineralisation is permitted to continue, it begins to affect the dentin layer. Remineralisation of dentin is not possible after caries formation. 5 There is an important balance between demineralisation and remineralisation processes. Increased demineralisation leads to caries progression, 3 while increased remineralisation leads to caries repair. Prophylactic application of

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“…[35] They work by subjecting the sample to intense pressure and high-velocity fluid flow, which helps break down and disperse the NPs uniformly within the liquid, as shown in Figure 4. [36] The key components of a high-pressure homogenizer include a high-pressure pump, a homogenizing valve or nozzle, and a chamber where the sample is processed. For example, Yujin Hwang reported the dispersion of carbon black in water and Ag NPs in silicon oil using oleic acid and SDS, respectively.…”

Section: Dispersing Of Uncoated Solid Npsmentioning

confidence: 99%

“…Due to the charge of NMs and the charge in the surrounding medium, different layers form around the NPs, as shown in Figure 6 Ref. [36] (Copyright 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim). [43] (Copyright 2015 Public Library of Science (PLOS).…”

Section: Electrostatic Stabilizationmentioning

confidence: 99%

Nanotechnology in the Fabrication of Advanced Paints and Coatings: Dispersion and Stabilization Mechanisms for Enhanced Performance

Azani,

Hassanpour

2024

ChemistrySelect

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This review comprehensively analyzes the challenge of dispersing and stabilizing of various common nanomaterials (NMs), including TiO₂, SiO₂, Ag, ZnO, graphene, carbon nanotubes (CNTs) and some others, in paints and coatings. It delves into the critical factors influencing dispersion, such as nanoparticle size, shape, concentration, and their distribution within the coating matrix.The review encompasses all stages of dispersion methods, including wetting, separation techniques, and stabilization. Regarding stabilization, both chemical and physical stabilization methods are discussed, along with their mechanisms, involving surface modification or functionalization of NMs, particularly tailored for aqueous and solvent‐based coatings and common resins (Acrylic, Urethane, Epoxy, Alkyd, etc.). Furthermore, common blending methods to fabricate uniform paints, coatings, and nanocomposites (NCPs) are examined. By providing a comprehensive understanding of the mechanisms governing NM dispersion and stabilization, this review facilitates the selection of appropriate surface modifications based on the specific resins or solvents, thereby enabling the fabrication of high‐performance paints and coatings. In summary, this review elucidates the essence of addressing the challenges associated with NM dispersion and stabilization, outlines methodologies employed, discusses findings regarding their effects on coating properties, and recommends tailored approaches for fabricating high‐performance paints and coatings.

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Synthesis of stabilized hydroxyapatite nanosuspensions for enamel caries remineralization

Abstract: High-pressure homogenization is an effective method for facile preparation of a stable suspension of hydroxyapatite nanoparticles. Treatment of artificial lesions with nonagglomerated spherical HA nanoparticles improves the remineralization of enamel lesion.

Cited by 11 publications

References 32 publications

Evaluation of The Effects of Different Remineralization agents on Initial Enamel Lesions by Scanning Electron Microscope and Energy-Distributed X-ray Analysis

Evaluation of The Effects of Different Remineralization agents on Initial Enamel Lesions by Scanning Electron Microscope and Energy-Distributed X-ray Analysis

Evaluation of the effects of different remineralisation agents on initial enamel lesions by scanning electron microscope and energy‐distributed X‐ray analysis

Nanotechnology in the Fabrication of Advanced Paints and Coatings: Dispersion and Stabilization Mechanisms for Enhanced Performance

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