Synthesis of Submicrocontainers with “Green” Biocide and Study of Their Antimicrobial Activity

Aidarova, Saule; Sharipova, А.; Issayeva, Assem B.; Mutaliyeva, B.; Tleuova, Aiym; Grigoriev, D. O.; Kudasova, Dariga; Dzhakasheva, M. A.; Miller, R.

doi:10.3390/colloids2040067

Cited by 8 publications

(14 citation statements)

References 36 publications

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“…However, the inactivation occurred more slowly indicating a gradual release of DCOIT from the SiNC, which release profile was demonstrated later by Figueiredo et al [36]. In this sense, Aidarova et al [70] reported an increase in inhibition of the microorganism growth (Aspergillus niger, Aspergillus awamori and Bacillus cereus) by the nanostructured form of DCOIT in comparison with the soluble form. The authors concluded that free biocide loses its activity more quickly, while the encapsulated biocide is released gradually, retaining 60% of its activity after 15 days of seeding.…”

Section: Ecotoxicity Assessmentmentioning

confidence: 83%

Marine Hazard Assessment of Soluble and Nanostructured Forms of the Booster Biocide DCOIT in Tropical Waters

Perina

Ottoni

Santos

et al. 2023

Water

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The encapsulation of antifouling compounds, such as DCOIT (4,5-Dichloro-2-octylisothiazol-3(2H)-one), in mesoporous silica nanocapsules (SiNC) has recently been demonstrated to be an eco-friendly alternative to decrease biocide toxicity towards marine non-target species. However, the lack of information on the chronic effects of such nanomaterials on non-target tropical species is critical for a more comprehensive environmental risk assessment. Thus, the present study aimed to assess the chronic toxicity and hazard of the soluble and encapsulated forms of DCOIT on neotropical marine species. Chronic tests were conducted with six ecologically relevant species. No effect concentration (NOEC) values were combined with NOEC values reported for tropical species to assess the hazard using the probabilistic approach to derive each predicted no effect concentration (PNEC). The SiNC-DCOIT was three- to ten-fold less toxic than soluble DCOIT. Probabilistic-based PNECs were set at 0.0001 and 0.0097 µg DCOIT L−1 for the biocide soluble and nanostructured forms, respectively. The immobilization of DCOIT into SiNC led to an 84-fold hazard decrease, confirming that the encapsulation of DCOIT into SiNC is a promising eco-friendly alternative technique, even in a chronic exposure scenario. Therefore, the present study will contribute to better management of the environmental risk of such innovative products in the tropical marine environment.

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Section: Ecotoxicity Assessmentmentioning

confidence: 83%

Marine Hazard Assessment of Soluble and Nanostructured Forms of the Booster Biocide DCOIT in Tropical Waters

Perina

Ottoni

Santos

et al. 2023

Water

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“…Compared with the EE (%) of organosilica nanocapsules containing DCOIT prepared by other methods, such as 3.8% by solvent evaporation method, 38 10% by Pickering emulsion polymerization method, 39 and 31.5% by drug impregnation method, 40 the EE (%) was as high as 49.15% by autocatalytic sol–gel method in this work, which also indicates that the prepared organosilica nanocapsules will have great application potential in encapsulating other kinds of oily core materials.…”

Section: Resultsmentioning

confidence: 99%

Preparation and evaluation of organosilica nanocapsules encapsulating DCOIT by using the response surface optimization

Liu

Lü

Cheng

et al. 2022

J of Applied Polymer Sci

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Antifouling agent 4, 5‐dichloro‐2‐n‐octyl‐4‐isothiazolin‐3‐one (DCOIT) in a one‐stage process based on the self‐catalytic reaction between methyl trimethoxysilane (MTMS) and 3‐aminopropyl trimethoxysilane (APS) in an aqueous system without any surfactants and catalysts have been developed. The optimal preparation process parameters of organosilica nanocapsules encapsulating DCOIT (DCOIT@SiNC) were determined using response surface methodology (RSM) based on the single‐factor experimental results. The results of RSM optimization showed that 49.51% encapsulation efficiency (EE [%]) would be achieved with a shell–core mass ratio of 5.59:1, a MTMS‐APS mole ratio of 1.52:1, and a reaction temperature of 31°C. DCOIT@SiNC prepared according to the RSM optimal process exhibited a decent uniform sphericity with an average particle diameter of 660.50 nm. The encapsulation was characterized by Fourier‐transform infrared and X‐ray diffraction. The loading efficiency and thermal stability were verified via thermogravimetric analysis. Compared to DCOIT, DCOIT@SiNC had better controlled release performance, and the release kinetics investigated by Riger‐peppas model indicated that the release of DCOIT was diffusion‐controlled.

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“…In our previous work [22], the colloid chemical properties of subnano-containers loaded with a biocide were studied by dynamic light scattering using the Zeta Sizer Nano ZS (Malvern Instruments, Great Britain).…”

Section: Resultsmentioning

confidence: 99%

“…Details of the synthesis of SMCs has been presented previously in [22]. To obtain a Pickering emulsion, the initial 40% concentrated suspension of hydrophilic non-aggregated amorphous silica particles was diluted about 15 times in deionized water, i.e., 2.0 g of a suspension of silica was added to 40 mL of deionized water containing 128 mg Irgacure 2959 as initiator (water solubility 7.6 g/L at 25 • C) (2-hydroxy-4'-(2 hydroxyethoxy))-2-methylpropiophenone.…”

Section: Preparation Of Smcsmentioning

confidence: 99%

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Analysis of NMR Spectra of Submicro-Containers with Biocide DCOIT

Aidarova

Issayeva

Sharipova

et al. 2020

Colloids and Interfaces

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Nowadays, the search for and development of new forms of materials with biocides is an actual problem of the modern science of nanosized materials due to the problem of microbiological contamination, which can be solved by using nanocontainers carrying biocides. Depending on the morphology of the nanocontainers and the filled active agents, it is possible to create coatings with specially designed self-healing functionality or multifunctional properties. The purpose of this work was to produce submicro-containers (SMCs) with a shell of SiO2 nanoparticles and a core of polymerized 3-(trimethoxysilyl) propyl methacrylate filled with 5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in an oil in water (O/W) emulsion. The chemical nature of the individual components of the system and nano-capsules were investigated using NMR spectroscopy. The size and zeta potential of the SMCs were measured by a dynamic light scattering method (d = 170–180 nm, polydispersity index PDI = 0.125 and zeta-potential = 55 mV), the morphology of their outer surface was determined using SEM. The results of NMR analysis showed that during the addition of the biocide into the SMCs, its chemical structure is retained, as is its activity. Minor changes in the chemical shifts of the 1H NMR spectra of the SMCs with DCOIT, as well as of the biocide itself, confirm the inclusion of DCOIT inside the SMCs.

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Synthesis of Submicrocontainers with “Green” Biocide and Study of Their Antimicrobial Activity

Cited by 8 publications

References 36 publications

Marine Hazard Assessment of Soluble and Nanostructured Forms of the Booster Biocide DCOIT in Tropical Waters

Marine Hazard Assessment of Soluble and Nanostructured Forms of the Booster Biocide DCOIT in Tropical Waters

Preparation and evaluation of organosilica nanocapsules encapsulating DCOIT by using the response surface optimization

Analysis of NMR Spectra of Submicro-Containers with Biocide DCOIT

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