Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

Kaoua, Rachedine; Bennamane, Norah; Bakhta, Saliha; Benadji, Sihame; Rabia, C.; Nedjar-Kolli, Bellara

doi:10.3390/molecules16010092

Cited by 32 publications

(17 citation statements)

References 42 publications

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“…Wells−Dawson heteropolyanion structure can be formulated as [(X n+ ) 2 M 18 O 62 ] (16−2n)− or [(X n+ ) 2 M 15 M 3´O62 ] (16−2n)− , where X n+ represents a central atom (heteroatom) such as P and Si, surrounded by a cage of M or M´addenda atoms, such as Mo 6+ or W 6+ or a mixture of elements. Recently, the use of heteropoly compounds as catalysts in both homogeneous and heterogeneous processes has attracted great interest in organic synthesis because their stronger Brö nsted acidity, their redox properties can be controlled at the molecular or atomic level and they also offer economical and environmental benefits [14], where the majority of POMs are not toxic and inexpensive [15]. Yamase [16], Song and Barteau [17] and Hiskia et al [18] have used the POMs as photocatalysts in many catalytic reactions and they proved that the POMs are well-organized metal-oxygen cluster anion, which initiates a variety of redox reactions under UV-illuminated condition [19].…”

Section: Introductionmentioning

confidence: 99%

Phenol photodegradation process assisted with Wells–Dawson heteropolyacids

Balaska

Samar²,

Grid³

2015

Desalination and Water Treatment

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A B S T R A C TThis work aims to investigate the catalytic properties of the heteropolyacids (HPAs) within photocatalytic process. Photocatalytic degradation of phenol in aqueous solution was performed using Wells-Dawson HPAs as catalysts under UV-illuminated condition at 254 nm. The effects of various parameters such as, concentration of catalyst, initial pH, and initial phenol concentration on the performance of photocatalytic process have been investigated to obtain the efficient and durable catalysts and determine the better reaction conditions. The kinetics and the efficiency of phenol degradation were determined by various analytical techniques, such as HPLC and TOC. The results show that the photocatalytic degradation efficiency increases with decreasing pH and the optimum pH is 2 for both catalysts. The photodegradation follows pseudo-first-order kinetics with rate constants k = 8.56 × 10 −2 and 9.94 × 10 −2 min −1 for iron-and vanadium-substituted HPAs, respectively.

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Section: Introductionmentioning

confidence: 99%

Phenol photodegradation process assisted with Wells–Dawson heteropolyacids

Balaska

Samar²,

Grid³

2015

Desalination and Water Treatment

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“…They show anticonvulsant, antianxiety, sedative, analgesic, anti‐depressant, hypnotic, antiviral, anti‐inflammatory, anti‐HIV, muscle relaxant, antiobesity, anticoagulant, antiulcer, calcium channel blocker, cholecystokinin antagonist, endothelin antagonist, thrombopoietin receptor agonist and vasopressin receptor antagonist activities . Some of their derivatives are used as dyes for acrylic fibers …”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structure and Computational Investigation of New 4‐Phenyl‐decahydro‐1H‐1,5‐benzodiazepin‐2‐one as Potent Inhibitor of Mu‐opioid Receptor

Garadi¹,

Bakri

Lai

et al. 2020

ChemistrySelect

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A novel benzodiazepine derivative was prepared and characterized by elemental analysis, FT-IR, NMR ( 1 H and 13 C) and HR-MS methods. Its crystal structure was also investigated by single crystal X-ray diffraction. In the title compound, the fused 6-and 7-membered rings adopt chair and "twist boat" conformations, respectively. In the crystal, the molecules form inversion dimers through N-H⋅⋅⋅O hydrogen bonds and pack with no unusually short intermolecular contacts, which is in agreement with the results of the Hirshfeld surface analysis.The Hirshfeld surface analysis showed that the H⋅⋅⋅H contact was the most important interaction for the studied compound. Based on the DFTÀ B3LYP study, the studied compound owned a little different geometry in the gas phase concerning the solid phase. The molecular docking was performed between the title compound and a mu-opioid receptor. Molecular dynamics studies were also carried up to 50 ns to understand the stability for the title compound complex with the mu-opioid receptor.[a] Dr.

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“…Microwave irradiation is well known to promote the synthesis of a variety of organic compounds, where chemical reactions are accelerated because of selective absorption of microwave by polar molecules. The synthesis of diazepines via various synthetic procedures under catalyzed conditions has widely been reported [2][3][4][5][6][7]. Diazepines and benzodiazepines have various therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Some New Benzodiazepinium Salt Derivatives under microwave Irradiation

Journal¹

2015

Baghdad Sci.J

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An attempt to synthesize the benzoimidazol derivatives from the reaction of o-phenylenediamine and benzoic acid derivatives in the presence of ethanol and various ketones under microwave irradiation, 1 , 5 - benzodiazepinum salt derivatives were obtained instead of them. Unexpected reaction was happened for synthesis a new series of benzodiazepinium salt derivatives in a selective yield . The reaction mechanism was also discussed. The new compounds were purified and identified their structures were elucidated using various physical techniques like; FT- IR spectra, micro elemental analysis (C.H.N) and 1H NMR spectra.

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Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

Cited by 32 publications

References 42 publications

Phenol photodegradation process assisted with Wells–Dawson heteropolyacids

Phenol photodegradation process assisted with Wells–Dawson heteropolyacids

Synthesis, Crystal Structure and Computational Investigation of New 4‐Phenyl‐decahydro‐1H‐1,5‐benzodiazepin‐2‐one as Potent Inhibitor of Mu‐opioid Receptor

Synthesis and Characterization of Some New Benzodiazepinium Salt Derivatives under microwave Irradiation

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