Synthesis of substituted 2,3-dihydro-1-(β-phenylethyl)-2-aryl and 2,3-diaryl-4(1H)-quinazolinones and their pharmacological activities

Two quinazolinones: a ring conformational study

“…Compounds (I) and (II) were prepared according to a literature procedure (Sadanandam et al, 1987) and were recrystallized from methanol.…”

Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using aluminum methanesulfonate as a reusable catalyst

“…2,3-Dihydroquinazolinone derivatives have been reported to possess a wide range of pharmacological activities such as anti-inflammatory and analgesic activities [1], and antitumor [2], anticancer [3], antibacterial [4], and diuretic activities [5]. In addition, these compounds as chemical intermediates can easily be oxidized to their corresponding quinazolin-4(3H)-ones [6], which are also important biologically active heterocyclic compounds [7,8].…”

“…The filtrate containing the catalyst was evaporated under reduced pressure to give the recovered catalyst, which could be reused without further treatment. The products were characterized by IR, 1 …”

Tris(Hydrogensulfato)Boron Catalysed Rapid Synthesis of 2-Substituted-2,3-Dihydroquinazolin-4(1H)-Ones under Solvent-Free Conditions

“…Recently, the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives have attracted great interest due to their biological and pharmacological activities. 1,2 They have been useful biological and pharmacological properties, such as anticancer, 3 antiinflammatory, 4 and anticonvulsant 5 activities. Quinazolinones are also important building blocks in the synthesis of natural products.…”